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Gene Review:

ZNF23 - zinc finger protein 23

Homo sapiens

Synonyms: KOX16, ZNF359, ZNF612, Zfp612, Zinc finger protein 23, ...

Zhou, L. et al., Huang, C. et al., Cannizzaro, L.A. et al.

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Psychiatry related information on ZNF23

Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development [1].

High impact information on ZNF23

Deletion analysis revealed that the effect of ZNF23 did not rely on its KRAB domain, but on the C-terminal zinc fingers [2].
Here we report that ZNF23, a member of KRAB-ZFPs, inhibits cell cycle progression [2].
Downregulation of p27(kip-1) by siRNA against p27(kip-1) reversed growth inhibition induced by ZNF23 [2].
Thus, ZNF19 and ZNF23 might be members of an evolutionarily conserved zinc finger gene cluster located on human chromosome 16q22 [3].
Northern blot analyses showed a strong expression of ZNF359 and ZFP28 in various tissues of adult human [1].

Biological context of ZNF23

The complete human ZNF359 cDNA sequence is 3270bp and contains a 1932-bp open reading frame (ORF) that encodes a 643 amino acid protein with an N-terminal KRAB domain and 16 C-terminus zinc finger C2H2 motifs [1].

References

Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. Zhou, L., Zhu, C., Luo, K., Li, Y., Pi, H., Yuan, W., Wang, Y., Huang, C., Liu, M., Wu, X. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression. Huang, C., Jia, Y., Yang, S., Chen, B., Sun, H., Shen, F., Wang, Y. Exp. Cell Res. (2007) [Pubmed]
Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24. Cannizzaro, L.A., Aronson, M.M., Thiesen, H.J. Hum. Genet. (1993) [Pubmed]

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