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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nkrf  -  NF-kappaB repressing factor

Mus musculus

Synonyms: 9430034D17Rik, AW124770, C80287, NF-kappa-B-repressing factor, NFkB-repressing factor, ...
 
 
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High impact information on Nkrf

  • NF-kappaB-repressing factor (NRF) is a transcriptional silencer protein that specifically counteracts the basal activity of several NF-kappaB-dependent promoters by direct binding to specific neighboring DNA sequences [1].
  • Against predictions from in vitro experiments, mice with a deletion of the NRF gene are viable and have a phenotype that is indistinguishable from wild-type mice, even after challenge with different pathogens [1].
  • Our results reveal a crucial role of Nrf-mediated gene expression in keratinocytes in the prevention of skin tumors and suggest that activation of Nrf2 in keratinocytes is a promising strategy to prevent carcinogenesis of this highly exposed organ [2].
  • Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing [2].
  • Northern blotting has shown that mouse small intestine contains relatively large amounts of the nuclear factor-E2 p45-related factor (Nrf) 2 transcription factor but relatively little Nrf1 [3].
 

Analytical, diagnostic and therapeutic context of Nkrf

  • In cell culture experiments, the reduction of NRF mRNA leads to a derepression of beta interferon, interleukin-8, and inducible nitric oxide synthase transcription [1].

References

  1. Innate immune responses in NF-kappaB-repressing factor-deficient mice. Froese, N., Schwarzer, M., Niedick, I., Frischmann, U., Köster, M., Kröger, A., Mueller, P.P., Nourbakhsh, M., Pasche, B., Reimann, J., Staeheli, P., Hauser, H. Mol. Cell. Biol. (2006) [Pubmed]
  2. Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing. Auf dem Keller, U., Huber, M., Beyer, T.A., Kümin, A., Siemes, C., Braun, S., Bugnon, P., Mitropoulos, V., Johnson, D.A., Johnson, J.A., Hohl, D., Werner, S. Mol. Cell. Biol. (2006) [Pubmed]
  3. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. McMahon, M., Itoh, K., Yamamoto, M., Chanas, S.A., Henderson, C.J., McLellan, L.I., Wolf, C.R., Cavin, C., Hayes, J.D. Cancer Res. (2001) [Pubmed]
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