Gene Review:
Nfe2 - nuclear factor, erythroid derived 2
Mus musculus
Synonyms:
Leucine zipper protein NF-E2, NF-E2, Nuclear factor, erythroid-derived 2 45 kDa subunit, Transcription factor NF-E2 45 kDa subunit, p45, ...
- Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer. Kotkow, K.J., Orkin, S.H. Mol. Cell. Biol. (1995)
- Ablation of Nrf2 function does not increase the erythroid or megakaryocytic cell lineage dysfunction caused by p45 NF-E2 gene disruption. Kuroha, T., Takahashi, S., Komeno, T., Itoh, K., Nagasawa, T., Yamamoto, M. J. Biochem. (1998)
- Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Shivdasani, R.A., Rosenblatt, M.F., Zucker-Franklin, D., Jackson, C.W., Hunt, P., Saris, C.J., Orkin, S.H. Cell (1995)
- Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Shivdasani, R.A., Orkin, S.H. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins. Igarashi, K., Kataoka, K., Itoh, K., Hayashi, N., Nishizawa, M., Yamamoto, M. Nature (1994)
- Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. Peters, L.L., Andrews, N.C., Eicher, E.M., Davidson, M.B., Orkin, S.H., Lux, S.E. Nature (1993)
- Regulation of NF-E2 activity in erythroleukemia cell differentiation. Nagai, T., Igarashi, K., Akasaka, J., Furuyama, K., Fujita, H., Hayashi, N., Yamamoto, M., Sassa, S. J. Biol. Chem. (1998)
- NF-E2p18/mafK is required in DMSO-induced differentiation of Friend erythroleukemia cells by enhancing NF-E2 activity. Francastel, C., Poindessous-Jazat, V., Augery-Bourget, Y., Robert-Lézénès, J. Leukemia (1997)
- Activation of beta-major globin gene transcription is associated with recruitment of NF-E2 to the beta-globin LCR and gene promoter. Sawado, T., Igarashi, K., Groudine, M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Martin, F., van Deursen, J.M., Shivdasani, R.A., Jackson, C.W., Troutman, A.G., Ney, P.A. Blood (1998)
- Histidine decarboxylase expression in mouse mast cell line P815 is induced by mouse peritoneal cavity incubation. Ohtsu, H., Kuramasu, A., Suzuki, S., Igarashi, K., Ohuchi, Y., Sato, M., Tanaka, S., Nakagawa, S., Shirato, K., Yamamoto, M., Ichikawa, A., Watanabe, T. J. Biol. Chem. (1996)
- The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. McMahon, M., Itoh, K., Yamamoto, M., Chanas, S.A., Henderson, C.J., McLellan, L.I., Wolf, C.R., Cavin, C., Hayes, J.D. Cancer Res. (2001)
- Role of AP1/NFE2 binding sites in endogenous alpha-globin gene transcription. Loyd, M.R., Okamoto, Y., Randall, M.S., Ney, P.A. Blood (2003)
- Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment. Toki, T., Katsuoka, F., Kanezaki, R., Xu, G., Kurotaki, H., Sun, J., Kamio, T., Watanabe, S., Tandai, S., Terui, K., Yagihashi, S., Komatsu, N., Igarashi, K., Yamamoto, M., Ito, E. Blood (2005)
- Multiple regions of p45 NF-E2 are required for beta-globin gene expression in erythroid cells. Bean, T.L., Ney, P.A. Nucleic Acids Res. (1997)
- Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation. Kerrigan, S.W., Gaur, M., Murphy, R.P., Shattil, S.J., Leavitt, A.D. Blood (2004)
- Cyclin D3 and megakaryocyte development: exploration of a transgenic phenotype. Zimmet, J.M., Toselli, P., Ravid, K. Stem Cells (1998)
- Regulation of globin gene transcription by heme in erythroleukemia cells: analysis of putative heme regulatory motifs in the p45 NF-E2 transcription factor. Moore, A., Boudia, M.M., Lehalle, D., Massrieh, W., Derjuga, A., Blank, V. Antioxid. Redox Signal. (2006)
- cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor. Chui, D.H., Tang, W., Orkin, S.H. Biochem. Biophys. Res. Commun. (1995)
- A role for Rab27b in NF-E2-dependent pathways of platelet formation. Tiwari, S., Italiano, J.E., Barral, D.C., Mules, E.H., Novak, E.K., Swank, R.T., Seabra, M.C., Shivdasani, R.A. Blood (2003)
- Nitric oxide-releasing agents and cGMP analogues inhibit murine erythroleukemia cell differentiation and suppress erythroid-specific gene expression: correlation with decreased DNA binding of NF-E2 and altered c-myb mRNA expression. Suhasini, M., Boss, G.R., Pascual, F.E., Pilz, R.B. Cell Growth Differ. (1995)
- Contiguous arrangement of p45 NFE2, HnRNP A1, and HP1 alpha on mouse chromosome 15 and human chromosome 12: evidence for suppression of these genes due to retroviral integration within the Fli-2 locus. Li, Y.J., Pak, B.J., Higgins, R.R., Lu, S.J., Ben-David, Y. Genes Chromosomes Cancer (2001)
- Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2. Chen, Z., Hu, M., Shivdasani, R.A. Blood (2007)
- Nuclear relocation of a transactivator subunit precedes target gene activation. Francastel, C., Magis, W., Groudine, M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. Levin, J., Peng, J.P., Baker, G.R., Villeval, J.L., Lecine, P., Burstein, S.A., Shivdasani, R.A. Blood (1999)
- Erythroid expression of the human alpha-spectrin gene promoter is mediated by GATA-1- and NF-E2-binding proteins. Boulanger, L., Sabatino, D.E., Wong, E.Y., Cline, A.P., Garrett, L.J., Garbarz, M., Dhermy, D., Bodine, D.M., Gallagher, P.G. J. Biol. Chem. (2002)
- Thrombopoietin can influence mature megakaryocytes to undergo further nuclear and cytoplasmic maturation. Tajika, K., Nakamura, H., Nakayama, K., Dan, K. Exp. Hematol. (2000)