Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

HMGN5 - high mobility group nucleosome binding...

Homo sapiens

Synonyms: High mobility group nucleosome-binding domain-containing protein 5, NBP-45, NSBP1, Nucleosome-binding protein 1

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Disease relevance of NSBP1

Identical questionnaires were given to a group of 51 patients with non-specific back pain (NSBP) attending an orthopaedic clinic [1].
CONCLUSION: This study suggests that hyperglycemia and higher NSBP levels should be responsible for an increased prevalence of LVH in hypertensive patients with Type 2 DM [2].

High impact information on NSBP1

Nonhistone chromosomal protein HMG-14 is a nucleosomal binding protein that unfolds the higher-order chromatin structure and enhances the transcriptional potential of chromatin, but not that of DNA [3].
The present paper, which is the first study on genes coding for this nucleosomal binding protein, indicates that the HMG-17 multigene family is the largest known human retropseudogene family [4].
NSBP1 is encoded by six exons and has exon-intron boundaries identical to the HMG-14/-17 genes [5].
Northern analysis of NSBP1/Nsbp1 shows differences in transcript abundance among adult and fetal tissues, with predominant expression in liver, kidney, trabecular bone, and bone marrow stromal cells [5].

References

Ankylosing spondylitis and trauma: the medicolegal implications. A comparative study of patients with non-specific back pain. Jacoby, R.K., Newell, R.L., Hickling, P. Ann. Rheum. Dis. (1985) [Pubmed]
Hyperglycemia and nocturnal systolic blood pressure are associatedwith left ventricular hypertrophy and diastolic dysfunction in hypertensive diabetic patients. Fel??cio, J.S., Pacheco, J.T., Ferreira, S.R., Plavnik, F., Mois??s, V.A., Kohlmann, O., Ribeiro, A.B., Zanella, M.T. Cardiovascular diabetology [electronic resource]. (2006) [Pubmed]
The chromatin unfolding domain of chromosomal protein HMG-14 targets the N-terminal tail of histone H3 in nucleosomes. Trieschmann, L., Martin, B., Bustin, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Retropseudogenes for human chromosomal protein HMG-17. Srikantha, T., Landsman, D., Bustin, M. J. Mol. Biol. (1987) [Pubmed]
Characterization of a human gene encoding nucleosomal binding protein NSBP1. King, L.M., Francomano, C.A. Genomics (2001) [Pubmed]

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