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Gene Review

SPAG16  -  sperm associated antigen 16

Homo sapiens

Synonyms: DKFZp666P1710, FLJ22724, PF20, Pf20 protein homolog, Sperm-associated antigen 16 protein, ...
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High impact information on SPAG16

  • Here, we investigated flagellum behaviour in normal and mutant trypanosome cell lines where expression of genes encoding various axoneme proteins (PF16, PF20, DNAI1, LC2) had been silenced by RNAi [1].
  • As flagella of Chlamydomonas strains carrying pf20 mutations lack the axonemal central complexes, we tested the involvement of the hPF20 gene in the disease phenotype of five patients in whom cilia or flagella display abnormal central complexes [2].
  • The hPF20 gene is expressed as two major transcripts: one is expressed in testis only, whereas the second is weakly expressed in many other tissues [2].
  • PF16, PF20 and KLP1 have been sequenced and their gene products localized [3].


  1. Conserved and specific functions of axoneme components in trypanosome motility. Branche, C., Kohl, L., Toutirais, G., Buisson, J., Cosson, J., Bastin, P. J. Cell. Sci. (2006) [Pubmed]
  2. Isolation and expression of the human hPF20 gene orthologous to Chlamydomonas PF20: evaluation as a candidate for axonemal defects of respiratory cilia and sperm flagella. Pennarun, G., Bridoux, A.M., Escudier, E., Dastot-Le Moal, F., Cacheux, V., Amselem, S., Duriez, B. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  3. The role of central apparatus components in flagellar motility and microtubule assembly. Smith, E.F., Lefebvre, P.A. Cell Motil. Cytoskeleton (1997) [Pubmed]
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