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Gene Review

Spag16  -  sperm associated antigen 16

Mus musculus

Synonyms: 4921511D23Rik, 4930524F24Rik, 4930585K05Rik, AV261009, Pf20, ...
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High impact information on Spag16


Biological context of Spag16

  • The different patterns of expression of the two PF20 proteins suggest the possibility that the Pf20 gene has multiple functions during spermatogenesis [1].
  • The murine Pf20 gene was mapped to chromosome 1, syntenic with the location of the human gene on chromosome 2 [2].
  • The sperm defect is consistent with the motility phenotype of the Pf20 mutants of Chlamydomonas, but morphologically different in that the mutant algal axoneme lacks the central apparatus [3].

Analytical, diagnostic and therapeutic context of Spag16


  1. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. Zhang, Z., Kostetskii, I., Moss, S.B., Jones, B.H., Ho, C., Wang, H., Kishida, T., Gerton, G.L., Radice, G.L., Strauss, J.F. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16. Zhang, Z., Sapiro, R., Kapfhamer, D., Bucan, M., Bray, J., Chennathukuzhi, V., McNamara, P., Curtis, A., Zhang, M., Blanchette-Mackie, E.J., Strauss, J.F. Mol. Cell. Biol. (2002) [Pubmed]
  3. Deficiency of SPAG16L causes male infertility associated with impaired sperm motility. Zhang, Z., Kostetskii, I., Tang, W., Haig-Ladewig, L., Sapiro, R., Wei, Z., Patel, A.M., Bennett, J., Gerton, G.L., Moss, S.B., Radice, G.L., Strauss, J.F. Biol. Reprod. (2006) [Pubmed]
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