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Gene Review

CHMP6  -  charged multivesicular body protein 6

Homo sapiens

Synonyms: Charged multivesicular body protein 6, Chromatin-modifying protein 6, FLJ11749, VPS20, Vacuolar protein sorting-associated protein 20, ...
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Disease relevance of CHMP6

  • Nevertheless, HIV-1 release and infectivity were not reduced by efficient small interfering RNA depletion of EAP20/ESCRT-II or CHMP6/ESCRT-III [1].
  • The in vitro pull-down assays using their recombinant proteins purified from Escherichia coli demonstrated direct physical interactions which were mediated by the N-terminal basic half of CHMP6 [2].

High impact information on CHMP6

  • The crystal structure of the C-terminal domain of Vps28 reveals a conserved surface required for Vps20 recruitment [3].
  • We show through mutagenesis studies that Vps28-CTD employs its strictly conserved surface in the interaction with the ESCRT-III factor Vps20 [3].
  • These results suggest that CHMP6 acts as an acceptor for ESCRT-II on endosomal membranes and regulates cargo sorting [2].
  • Various CHMP6 orthologues in organisms ranging from yeast to humans contain the N-myristoylation consensus sequence at each N-terminus [2].
  • CHMP6 (charged multivesicular body protein 6) is a human orthologue of yeast Vps (vacuolar protein sorting) 20, a component of ESCRT (endosomal sorting complex required for transport)-III [2].

Associations of CHMP6 with chemical compounds

  • Interestingly, overexpression of both hSnf7 and hVps20 proteins induced a post-endosomal defect in cholesterol sorting [4].
  • Snf7p (sucrose non-fermenting) and Vps20p (vacuolar protein-sorting) are small coil-coiled proteins involved in yeast MVB (multivesicular body) structure, formation and function [4].


  1. Human ESCRT-II Complex and Its Role in Human Immunodeficiency Virus Type 1 Release. Langelier, C., von Schwedler, U.K., Fisher, R.D., De Domenico, I., White, P.L., Hill, C.P., Kaplan, J., Ward, D., Sundquist, W.I. J. Virol. (2006) [Pubmed]
  2. Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting. Yorikawa, C., Shibata, H., Waguri, S., Hatta, K., Horii, M., Katoh, K., Kobayashi, T., Uchiyama, Y., Maki, M. Biochem. J. (2005) [Pubmed]
  3. The crystal structure of the C-terminal domain of Vps28 reveals a conserved surface required for Vps20 recruitment. Pineda-Molina, E., Belrhali, H., Piefer, A.J., Akula, I., Bates, P., Weissenhorn, W. Traffic (2006) [Pubmed]
  4. Structure and function of human Vps20 and Snf7 proteins. Peck, J.W., Bowden, E.T., Burbelo, P.D. Biochem. J. (2004) [Pubmed]
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