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Gene Review

HSPBAP1  -  HSPB (heat shock 27kDa) associated protein 1

Homo sapiens

Synonyms: 27 kDa heat shock protein-associated protein 1, FLJ22623, HSPB1-associated protein 1, PASS1, Protein associated with small stress protein 1
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High impact information on HSPBAP1

  • This splice results in the formation of DIRC3-HSPBAP1 fusion transcripts [1].
  • We propose that these fusion transcripts may affect normal HSPBAP1 function and concomitant chromatin remodeling and/or stress response signals within t(2;3)(q35;q21)-positive kidney cells [1].
  • According to bioinformatics analysis, the HSPBAP1 gene is located on chromosome 3q21 [2].
  • RT-PCR analysis indicated that HSPBAP1 was abundant in thymus and pancreas but had a ubiquitously low expression pattern in other human adult tissues except for brain where it was absent [2].
  • Rat PASS1 is a novel protein binding specifically to hsp27 and thus plays a role in regulating stress response in the living cell [2].

Biological context of HSPBAP1

  • In addition, we found that the first two exons of DIRC3 can splice to the second exon of HSPBAP1, a JmjC-Hsp27 domain gene that maps proximal to the breakpoint on chromosome 3 [1].

Analytical, diagnostic and therapeutic context of HSPBAP1


  1. Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t(2;3)(q35;q21). Bodmer, D., Schepens, M., Eleveld, M.J., Schoenmakers, E.F., Geurts van Kessel, A. Genes Chromosomes Cancer (2003) [Pubmed]
  2. Molecular cloning and characterization of a novel human gene (HSPBAP1) from human fetal brain. Jiang, M., Ma, Y., Cheng, H., Ni, X., Guo, L., Xie, Y., Mao, Y. Cytogenet. Cell Genet. (2001) [Pubmed]
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