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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MANEA  -  mannosidase, endo-alpha

Homo sapiens

Synonyms: ENDO, Endo-alpha mannosidase, Endomannosidase, FLJ12838, Glycoprotein endo-alpha-1,2-mannosidase, ...
 
 
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High impact information on MANEA

  • We constructed a recombinant adenoviral vector carrying the human endostatin gene (Ad/hEndo), which expressed high-level endostatin protein in NPC CNE-2 cells, and significantly inhibited the proliferation and migration of vascular endothelial cells in vitro [1].
  • The therapeutically relevant endostatin transgene expression was achieved during the course of multiple intra-tumoral administrations with Ad/hEndo [1].
  • Ad/hEndo significantly inhibited HUVEC cell proliferation by 57.2% at a multiplicity of infection (MOI) of 20 [2].
  • In this study, we observed the effect and advantage of endostatin gene therapy mediated by a recombinant adenoviral vector (Ad/hEndo) on the growth of hepatocellular carcinoma BEL-7402 xenografted tumors, comparison with recombinant endostatin protein [3].
 

Analytical, diagnostic and therapeutic context of MANEA

  • After 6-week treatment with Ad/hEndo, the growth of treated tumors was inhibited by 46.50% compared to the Ad/LacZ control group (t=2.729, P<0.05) and by 48.56% compared to the DMEM control group (t=2.485, P<0.05) [2].
  • After intra-tumoral administration with Ad/hEndo, the endostatin mRNA expression in tumor tissue was analyzed by Northern blotting, and plasma endostatin levels were determined using enzyme-linked immunosorbent assay (ELISA) [2].
  • METHODS: Immunohistochemistry analysis with an anti-endostatin antibody was preformed to detect endostatin protein expression in HCC BEL-7402 cells infected with Ad/hEndo [2].
  • The expression of endostatin mRNA in tumor tissue was analyzed by reverse transcription-polymerase chain reaction (RT-PCR) after Ad/hEndo injection [3].

References

  1. Adenovirus-mediated intra-tumoral delivery of the human endostatin gene inhibits tumor growth in nasopharyngeal carcinoma. Li, L., Liu, R.Y., Huang, J.L., Liu, Q.C., Li, Y., Wu, P.H., Zeng, Y.X., Huang, W. Int. J. Cancer (2006) [Pubmed]
  2. Endostatin gene therapy for liver cancer by a recombinant adenovirus delivery. Li, L., Huang, J.L., Liu, Q.C., Wu, P.H., Liu, R.Y., Zeng, Y.X., Huang, W.L. World J. Gastroenterol. (2004) [Pubmed]
  3. Inhibition of tumor growth in xenografted nude mice with adenovirus-mediated endostatin gene comparison with recombinant endostatin protein. Liang, Z.H., Wu, P.H., Li, L., Xue, G., Zeng, Y.X., Huang, W.L. Chin. Med. J. (2004) [Pubmed]
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