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Gene Review

NEK11  -  NIMA-related kinase 11

Homo sapiens

Synonyms: FLJ23495, Never in mitosis A-related kinase 11, NimA-related protein kinase 11, Serine/threonine-protein kinase Nek11
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High impact information on NEK11

  • Moreover, Nek2 directly phosphorylated Nek11 in the C-terminal non-catalytic region and elevated Nek11 kinase activity [1].
  • The non-catalytic region of Nek11 showed autoinhibitory activity through intramolecular interaction with its N-terminal catalytic domain [1].
  • We found an activation of Nek11 kinase activity when cells were treated with various DNA-damaging agents and replication inhibitors, and this activation of Nek11 was suppressed by caffeine in HeLaS3 cells [2].
  • The expression of nek11L mRNA increased through S to G(2)/M phase, and subcellular localization of Nek11 protein altered between interphase and prometaphase, suggesting multiple roles of Nek11 [2].
  • Collectively, these results suggest that Nek11 has a role in the S-phase checkpoint downstream of the caffeine-sensitive pathway [2].

Biological context of NEK11


  1. Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells. Noguchi, K., Fukazawa, H., Murakami, Y., Uehara, Y. J. Biol. Chem. (2004) [Pubmed]
  2. Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses. Noguchi, K., Fukazawa, H., Murakami, Y., Uehara, Y. J. Biol. Chem. (2002) [Pubmed]
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