The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Prometaphase

  • SNM and MNM colocalize along with a repetitive rDNA sequence known to function as an X-Y pairing site to nucleolar foci during meiotic prophase and to a compact structure associated with the X-Y bivalent during prometaphase I and metaphase I [1].
  • Diazepam induces mitotic arrest at prometaphase by inhibiting centriolar separation [2].
  • In vertebrate cells, arm cohesion is largely lost during prophase and prometaphase in order to facilitate sister chromatid resolution, whereas centromeric cohesion is preserved until the bipolar attachment of sister chromatids is established [3].
  • Thus it appears that MEI-S332 assembles into a multimeric protein complex that localizes to centromeric regions during prometaphase and is required for the maintenance of sister-chromatid cohesion until anaphase, rather than its establishment in S phase [4].
  • The abundant coiled-coil protein NuMA is located in the nucleus during interphase, but when the nuclear envelope disassembles in prometaphase it rapidly redistributes to the developing spindle poles [5].

Biological context of Prometaphase


Anatomical context of Prometaphase


Associations of Prometaphase with chemical compounds


Gene context of Prometaphase


Analytical, diagnostic and therapeutic context of Prometaphase


  1. Identification of two proteins required for conjunction and regular segregation of achiasmate homologs in Drosophila male meiosis. Thomas, S.E., Soltani-Bejnood, M., Roth, P., Dorn, R., Logsdon, J.M., McKee, B.D. Cell (2005) [Pubmed]
  2. Diazepam induces mitotic arrest at prometaphase by inhibiting centriolar separation. Andersson, L.C., Lehto, V.P., Stenman, S., Badley, R.A., Virtanen, I. Nature (1981) [Pubmed]
  3. Shugoshin: guardian spirit at the centromere. Watanabe, Y. Curr. Opin. Cell Biol. (2005) [Pubmed]
  4. Maintenance of sister-chromatid cohesion at the centromere by the Drosophila MEI-S332 protein. Tang, T.T., Bickel, S.E., Young, L.M., Orr-Weaver, T.L. Genes Dev. (1998) [Pubmed]
  5. NuMA: a protein involved in nuclear structure, spindle assembly, and nuclear re-formation. Cleveland, D.W. Trends Cell Biol. (1995) [Pubmed]
  6. Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression. Shu, T., Tseng, H.C., Sapir, T., Stern, P., Zhou, Y., Sanada, K., Fischer, A., Coquelle, F.M., Reiner, O., Tsai, L.H. Neuron (2006) [Pubmed]
  7. Poleward microtubule flux mitotic spindles assembled in vitro. Sawin, K.E., Mitchison, T.J. J. Cell Biol. (1991) [Pubmed]
  8. The maize homologue of the cell cycle checkpoint protein MAD2 reveals kinetochore substructure and contrasting mitotic and meiotic localization patterns. Yu, H.G., Muszynski, M.G., Kelly Dawe, R. J. Cell Biol. (1999) [Pubmed]
  9. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. Basu, J., Bousbaa, H., Logarinho, E., Li, Z., Williams, B.C., Lopes, C., Sunkel, C.E., Goldberg, M.L. J. Cell Biol. (1999) [Pubmed]
  10. Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. Tatsumoto, T., Xie, X., Blumenthal, R., Okamoto, I., Miki, T. J. Cell Biol. (1999) [Pubmed]
  11. Initiation and growth of microtubules from mitotic centers in lysed mammalian cells. Snyder, J.A., McIntosh, J.R. J. Cell Biol. (1975) [Pubmed]
  12. Mechanism of the formation of contractile ring in dividing cultured animal cells. I. Recruitment of preexisting actin filaments into the cleavage furrow. Cao, L.G., Wang, Y.L. J. Cell Biol. (1990) [Pubmed]
  13. RAF1-activated MEK1 is found on the Golgi apparatus in late prophase and is required for Golgi complex fragmentation in mitosis. Colanzi, A., Sutterlin, C., Malhotra, V. J. Cell Biol. (2003) [Pubmed]
  14. Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis. van Vugt, M.A., van de Weerdt, B.C., Vader, G., Janssen, H., Calafat, J., Klompmaker, R., Wolthuis, R.M., Medema, R.H. J. Biol. Chem. (2004) [Pubmed]
  15. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. Williams, B.C., Li, Z., Liu, S., Williams, E.V., Leung, G., Yen, T.J., Goldberg, M.L. Mol. Biol. Cell (2003) [Pubmed]
  16. Kinetochore microtubule dynamics and the metaphase-anaphase transition. Zhai, Y., Kronebusch, P.J., Borisy, G.G. J. Cell Biol. (1995) [Pubmed]
  17. Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development. Hanson, K.K., Kelley, A.C., Bienz, M. Development (2005) [Pubmed]
  18. Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression. Choudhury, A.D., Xu, H., Baer, R. J. Biol. Chem. (2004) [Pubmed]
  19. A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment. Wakefield, J.G., Stephens, D.J., Tavaré, J.M. J. Cell. Sci. (2003) [Pubmed]
  20. Initiation of DNA replication cycle in fertilized eggs of the starfish, Asterina pectinifera. Nomura, A., Maruyama, Y.K., Yoneda, M. Dev. Biol. (1991) [Pubmed]
  21. Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein. Wojcik, E., Basto, R., Serr, M., Scaërou, F., Karess, R., Hays, T. Nat. Cell Biol. (2001) [Pubmed]
  22. Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression. Gabellini, D., Colaluca, I.N., Vodermaier, H.C., Biamonti, G., Giacca, M., Falaschi, A., Riva, S., Peverali, F.A. EMBO J. (2003) [Pubmed]
  23. Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest. Ohsumi, K., Koyanagi, A., Yamamoto, T.M., Gotoh, T., Kishimoto, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  24. Retention of the BUB3 checkpoint protein on lagging chromosomes. Martinez-Exposito, M.J., Kaplan, K.B., Copeland, J., Sorger, P.K. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  25. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. Wang, X., Babu, J.R., Harden, J.M., Jablonski, S.A., Gazi, M.H., Lingle, W.L., de Groen, P.C., Yen, T.J., van Deursen, J.M. J. Biol. Chem. (2001) [Pubmed]
  26. Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation. Howell, B.J., McEwen, B.F., Canman, J.C., Hoffman, D.B., Farrar, E.M., Rieder, C.L., Salmon, E.D. J. Cell Biol. (2001) [Pubmed]
  27. Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition. Sumi, T., Hashigasako, A., Matsumoto, K., Nakamura, T. Exp. Cell Res. (2006) [Pubmed]
  28. P2P-R protein overexpression restricts mitotic progression at prometaphase and promotes mitotic apoptosis. Gao, S., Scott, R.E. J. Cell. Physiol. (2002) [Pubmed]
  29. A high-resolution cytogenetic map of human chromosome 3: localization of 291 new cosmid markers by direct R-banding fluorescence in situ hybridization. Takahashi, E., Yamakawa, K., Nakamura, Y., Hori, T. Genomics (1992) [Pubmed]
WikiGenes - Universities