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Gene Review

SPSB1  -  splA/ryanodine receptor domain and SOCS...

Homo sapiens

Synonyms: SPRY domain-containing SOCS box protein 1, SSB-1, SSB1
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High impact information on SPSB1

  • This observation led to a facile identification of the Glu-Leu-Asn-Asn-Asn-Leu sequence as the recognition motif in a proapoptotic protein Par-4 for its interaction with a GUSTAVUS homolog, SSB-1 [1].
  • We demonstrated that SSB-1 bound to MET tyrosine kinase domain through its SPRY domain [2].
  • The phosphorylated SSB-1 protein bound to p120Ras-GTPase-activating protein (GAP) but did not promote the degradation of p120RasGAP, indicating that enhanced HGF-MET signaling by overexpression of SSB-1 was not dependent on p120RasGAP degradation [2].
  • Suppression of SSB-1 by the RNA interference method down-regulated HGF-induced SRE-luciferase activity and decreased Elk-1 activation [2].
  • SSB-1 also enhanced HGF-induced Erk phosphorylation [2].

Biological context of SPSB1


Associations of SPSB1 with chemical compounds

  • Each of these substrates induced specific amide (1)H and/or (15)N chemical shift changes in both the NTD and SSB1 [3].


  1. Structural Basis for Protein Recognition by B30.2/SPRY Domains. Woo, J.S., Suh, H.Y., Park, S.Y., Oh, B.H. Mol. Cell (2006) [Pubmed]
  2. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. Wang, D., Li, Z., Messing, E.M., Wu, G. J. Biol. Chem. (2005) [Pubmed]
  3. The weak interdomain coupling observed in the 70 kDa subunit of human replication protein A is unaffected by ssDNA binding. Daughdrill, G.W., Ackerman, J., Isern, N.G., Botuyan, M.V., Arrowsmith, C., Wold, M.S., Lowry, D.F. Nucleic Acids Res. (2001) [Pubmed]
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