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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

COX1  -  cytochrome c oxidase subunit I

Canis lupus familiaris

 
 
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High impact information on COX1

  • The other compounds tested did not have substantial selectivity for canine COX2 or were more selective for canine COX1 [1].
  • Activity of carprofen and other NSAID against COX1 and COX2 was compared [1].
  • Ratio of the COX1-to-COX2 IC50 was used as a measure of isozyme selectivity [1].
 

Anatomical context of COX1

  • PROCEDURE: Constitutive COX1 was obtained from washed canine platelets, and COX2 was obtained from a canine macrophage-like cell line that was induced with endotoxin [1].

References

  1. Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other nonsteroidal anti-inflammatory drugs. Ricketts, A.P., Lundy, K.M., Seibel, S.B. Am. J. Vet. Res. (1998) [Pubmed]
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