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Gene Review

COX1  -  cytochrome c oxidase subunit I

Canis lupus familiaris

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High impact information on COX1

  • The other compounds tested did not have substantial selectivity for canine COX2 or were more selective for canine COX1 [1].
  • Activity of carprofen and other NSAID against COX1 and COX2 was compared [1].
  • Ratio of the COX1-to-COX2 IC50 was used as a measure of isozyme selectivity [1].

Anatomical context of COX1

  • PROCEDURE: Constitutive COX1 was obtained from washed canine platelets, and COX2 was obtained from a canine macrophage-like cell line that was induced with endotoxin [1].


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