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Gene Review

cox1  -  cytochrome c oxidase 1

Schizosaccharomyces pombe

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Disease relevance of cox1


High impact information on cox1


Biological context of cox1

  • As was seen for the Sch. pombe cox1 gene (Lang, 1984), the cob exons are translated using the universal genetic code and this distinguishes Sch. pombe mitochondria from all other fungal and animal mitochondrial systems [4].
  • The biogenesis of cytochrome c oxidase requires coordination between the nucleus and mitochondria because both these compartments provide the structural subunits of this enzyme [5].

Anatomical context of cox1


Associations of cox1 with chemical compounds


  1. The mitochondrial genome of Schizosaccharomyces pombe. Stimulation of intra-chromosomal recombination in Escherichia coli by the gene product of the first cox1 intron. Manna, F., Massardo, D.R., Del Giudice, L., Buonocore, A., Nappo, A.G., Alifano, P., Schäfer, B., Wolf, K. Curr. Genet. (1991) [Pubmed]
  2. The mitochondrial genome of the fission yeast Schizosaccharomyces pombe: highly homologous introns are inserted at the same position of the otherwise less conserved cox1 genes in Schizosaccharomyces pombe and Aspergillus nidulans. Lang, B.F. EMBO J. (1984) [Pubmed]
  3. Functional analysis of the domains in Cox11. Carr, H.S., Maxfield, A.B., Horng, Y.C., Winge, D.R. J. Biol. Chem. (2005) [Pubmed]
  4. The mitochondrial genome of the fission yeast Schizosaccharomyces pombe. The cytochrome b gene has an intron closely related to the first two introns in the Saccharomyces cerevisiae cox1 gene. Lang, B.F., Ahne, F., Bonen, L. J. Mol. Biol. (1985) [Pubmed]
  5. The COX18 gene, involved in mitochondrial biogenesis, is functionally conserved and tightly regulated in humans and fission yeast. Gaisne, M., Bonnefoy, N. FEMS Yeast Res. (2006) [Pubmed]
  6. Purification of the Chlorella HUP1 hexose-proton symporter to homogeneity and its reconstitution in vitro. Caspari, T., Robl, I., Stolz, J., Tanner, W. Plant J. (1996) [Pubmed]
  7. The HUP1 gene product of Chlorella kessleri: H+/glucose symport studied in vitro. Opekarová, M., Caspari, T., Tanner, W. Biochim. Biophys. Acta (1994) [Pubmed]
  8. Fractionation by differential and zonal centrifugation of spheroplasts prepared from a glucose-repressed fission yeast Schizosaccharomyces pombe 972h-. Poole, R.K., Lloyd, D. J. Gen. Microbiol. (1976) [Pubmed]
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