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Chemical Compound Review

Norocarp     2-(6-chloro-9H-carbazol-2- yl)propanoic acid

Synonyms: Carpaquin, Carprodyl, Ridamyl, Rimadyl, carprofen, ...
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Disease relevance of C 5720


Psychiatry related information on C 5720

  • N-sulfonylated and N-alkylated carprofen derivatives were investigated for their inhibition and modulation of gamma-secretase, which is associated with Alzheimer's disease [5].
  • Two crossover bioequivalence trials of an enantioselectively enterohepatic recycled drug, carprofen, were conducted in dogs with the same racemic oral formulation to determine: (i) the influence of feeding patterns, and (ii) the effect of the analytical method (enantioselective vs non-enantioselective) on the statistical power of the trials [6].
  • Mechanical pain threshold testing at the wound showed a significant analgesic effect of carprofen [7].

High impact information on C 5720


Chemical compound and disease context of C 5720


Biological context of C 5720


Anatomical context of C 5720


Associations of C 5720 with other chemical compounds


Gene context of C 5720


Analytical, diagnostic and therapeutic context of C 5720

  • Circular dichroism data suggested different mechanisms for the high affinity and the low affinity binding of carprofen to HSA [32].
  • Reference diastereomeric glucuronides of carprofen were purified from human urine after oral administration of the single enantiomers [33].
  • Following every drug administration, blood samples were collected over a period of 104 h and carprofen plasma concentrations were measured by a specific HPLC method with UV detection [19].
  • Analysis of carprofen dosage forms and drug substance by high-performance liquid chromatography [34].
  • The calculation of the tubular transit rate at each carprofen concentration indicated the following net mechanism(s) of renal carprofen clearance: filtration at low concentration, reabsorption at intermediate concentrations, and secretion at the highest concentration [35].


  1. Carprofen reduces the structural changes and the abnormal subchondral bone metabolism of experimental osteoarthritis. Pelletier, J.P., Lajeunesse, D., Hilal, G., Jovanovic, D., Fernandes, J.C., Martel-Pelletier, J. Osteoarthr. Cartil. (1999) [Pubmed]
  2. The influence of liver dysfunction on the pharmacokinetics of carprofen. Holazo, A.A., Chen, S.S., McMahon, F.G., Ryan, J.R., Konikoff, J.J., Brazzell, R.K. Journal of clinical pharmacology. (1985) [Pubmed]
  3. Pharmacokinetic and clinical studies of carprofen in gout. Yü, T.F., Perel, J. Journal of clinical pharmacology. (1980) [Pubmed]
  4. Occupational photoallergic contact dermatitis in a pharmaceutical worker manufacturing carprofen, a canine nonsteroidal anti-inflammatory drug. Walker, S.L., Ead, R.D., Beck, M.H. Br. J. Dermatol. (2006) [Pubmed]
  5. Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators. Narlawar, R., Pérez Revuelta, B.I., Haass, C., Steiner, H., Schmidt, B., Baumann, K. J. Med. Chem. (2006) [Pubmed]
  6. Influence of feeding and analytical method on the bioequivalence of a racemic drug undergoing enantioselective enterohepatic recycling. Priymenko, N.M., Koritz, G.D., Ferre, J.P., Laroute, V.M., Toutain, P.L. Journal of pharmaceutical sciences. (2004) [Pubmed]
  7. Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy. Lascelles, B.D., Cripps, P.J., Jones, A., Waterman-Pearson, A.E. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (1998) [Pubmed]
  8. Serum concentration and dose-response relationships for carprofen in rheumatoid arthritis. Furst, D.E., Caldwell, J.R., Klugman, M.P., Enthoven, D., Rittweger, K., Scheer, R., Sarkissian, E., Dromgoole, S. Clin. Pharmacol. Ther. (1988) [Pubmed]
  9. Quantitation of biliary excretion of drugs in man. Dujovne, C.A., Gustafson, J.H., Dickey, R.A. Clin. Pharmacol. Ther. (1982) [Pubmed]
  10. Behavioural effects of laparotomy and analgesic effects of ketoprofen and carprofen in rats. Roughan, J.V., Flecknell, P.A. Pain (2001) [Pubmed]
  11. Pharmacokinetic drug interactions with nonsteroidal anti-inflammatory drugs. Verbeeck, R.K. Clinical pharmacokinetics. (1990) [Pubmed]
  12. Neuroprotective properties of different anesthetics on axotomized rat retinal ganglion cells in vivo. Ozden, S., Isenmann, S. J. Neurotrauma (2004) [Pubmed]
  13. Comparison of ketoprofen and carprofen administered prior to orthopedic surgery for control of postoperative pain in dogs. Grisneaux, E., Pibarot, P., Dupuis, J., Blais, D. J. Am. Vet. Med. Assoc. (1999) [Pubmed]
  14. Clinical evaluation of a nutraceutical, carprofen and meloxicam for the treatment of dogs with osteoarthritis. Moreau, M., Dupuis, J., Bonneau, N.H., Desnoyers, M. Vet. Rec. (2003) [Pubmed]
  15. Clinical evaluation of firocoxib and carprofen for the treatment of dogs with osteoarthritis. Pollmeier, M., Toulemonde, C., Fleishman, C., Hanson, P.D. Vet. Rec. (2006) [Pubmed]
  16. Effects of carprofen and dexamethasone on canine chondrocytes in a three-dimensional culture model of osteoarthritis. Dvorak, L.D., Cook, J.L., Kreeger, J.M., Kuroki, K., Tomlinson, J.L. Am. J. Vet. Res. (2002) [Pubmed]
  17. In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis. Sessions, J.K., Reynolds, L.R., Budsberg, S.C. Am. J. Vet. Res. (2005) [Pubmed]
  18. Study of interaction of carprofen and its enantiomers with human serum albumin--II. Stereoselective site-to-site displacement of carprofen by ibuprofen. Rahman, M.H., Maruyama, T., Okada, T., Imai, T., Otagiri, M. Biochem. Pharmacol. (1993) [Pubmed]
  19. Influence of the hydrophilicity of suppository bases on rectal absorption of carprofen, a lipophilic nonsteroidal anti-inflammatory drug. Schmitt, M., Guentert, T.W. Journal of pharmaceutical sciences. (1990) [Pubmed]
  20. Effects of indomethacin and carprofen on renal homeostasis in rheumatoid arthritis patients and in healthy individuals. Williams, R.L., Furst, D.E., Mandel, H.G., Nicoll, D., Konikoff, J.J., Benet, L.Z. Journal of clinical pharmacology. (1981) [Pubmed]
  21. Metabolism of carprofen, a nonsteroid anti-inflammatory agent, in rats, dogs, and humans. Rubio, F., Seawall, S., Pocelinko, R., DeBarbieri, B., Benz, W., Berger, L., Morgan, L., Pao, J., Williams, T.H., Koechlin, B. Journal of pharmaceutical sciences. (1980) [Pubmed]
  22. Effects of prostaglandin synthesis inhibition on the immune response. Schleimer, R.P., Benjamini, E. Immunopharmacology (1981) [Pubmed]
  23. Enhancement by carprofen or indomethacin of interferon induction by 10-carboxymethyl-9-acridanone in murine cell cultures. Storch, E., Kirchner, H., Hüller, K., Martinotti, M.G., Gemsa, D. J. Gen. Virol. (1986) [Pubmed]
  24. Pharmacokinetics of carprofen in plasma and synovial fluid. Ray, J.E., Wade, D.N., Graham, G.G., Day, R.O. Journal of clinical pharmacology. (1979) [Pubmed]
  25. Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis. Pelletier, J.P., Lajeunesse, D., Jovanovic, D.V., Lascau-Coman, V., Jolicoeur, F.C., Hilal, G., Fernandes, J.C., Martel-Pelletier, J. J. Rheumatol. (2000) [Pubmed]
  26. Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin. Iwakawa, S., Spahn, H., Benet, L.Z., Lin, E.T. Biochem. Pharmacol. (1990) [Pubmed]
  27. A rapid sensitive determination of carprofen and zomepirac using thin-layer chromatography and gas chromatography--mass spectrometry. Dettwiler, M., Rippstein, S., Jeger, A. J. Chromatogr. (1982) [Pubmed]
  28. Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats. Giraudel, J.M., Toutain, P.L., Lees, P. Am. J. Vet. Res. (2005) [Pubmed]
  29. Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Bryant, C.E., Farnfield, B.A., Janicke, H.J. Am. J. Vet. Res. (2003) [Pubmed]
  30. Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Wilson, J.E., Chandrasekharan, N.V., Westover, K.D., Eager, K.B., Simmons, D.L. Am. J. Vet. Res. (2004) [Pubmed]
  31. Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other nonsteroidal anti-inflammatory drugs. Ricketts, A.P., Lundy, K.M., Seibel, S.B. Am. J. Vet. Res. (1998) [Pubmed]
  32. Study of interaction of carprofen and its enantiomers with human serum albumin--I. Mechanism of binding studied by dialysis and spectroscopic methods. Rahman, M.H., Maruyama, T., Okada, T., Yamasaki, K., Otagiri, M. Biochem. Pharmacol. (1993) [Pubmed]
  33. Direct determination of diastereomeric carprofen glucuronides in human plasma and urine and preliminary measurements of stereoselective metabolic and renal elimination after oral administration of carprofen in man. Iwakawa, S., Suganuma, T., Lee, S.F., Spahn, H., Benet, L.Z., Lin, E.T. Drug Metab. Dispos. (1989) [Pubmed]
  34. Analysis of carprofen dosage forms and drug substance by high-performance liquid chromatography. Ross, A.J., Del Mauro, M.D., Sokoloff, H.K., Casey, D.L. Journal of pharmaceutical sciences. (1984) [Pubmed]
  35. Renal clearance of carprofen in the isolated perfused rat kidney. Bekersky, I., Colburn, W.A. Drug Metab. Dispos. (1981) [Pubmed]
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