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Gene Review:

COX1 - cytochrome c oxidase subunit I

Felis catus

Giraudel, J.M. et al., Landolfi, J.A. et al.

Landolfi, Terio,

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High impact information on COX1

Inhibition of thromboxane B2 production, measured by use of a radioimmunoassay, was taken as a marker of COX-1 and COX-2 activities [1].
These assays were used to test 10 to 12 concentrations of a COX-1 selective drug (SC-560) and of 2 NSAIDs currently used in feline practice, meloxicam and carprofen [1].

Associations of COX1 with chemical compounds

PROCEDURE: COX-1 and COX-2 activities in heparinized whole blood samples were induced with calcium ionophore and lipopolysaccharide, respectively [1].

Other interactions of COX1

The COX-1 and COX-2 assays were standardized, such that time courses of incubation with the test compounds and conditions of COX expression were as similar as possible in the 2 assays [1].

Analytical, diagnostic and therapeutic context of COX1

COX-1 immunohistochemistry was negative in all cases [2].

References

Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats. Giraudel, J.M., Toutain, P.L., Lees, P. Am. J. Vet. Res. (2005) [Pubmed]
Transitional Cell Carcinoma in Fishing Cats (Prionailurus viverrinus): Pathology and Expression of Cyclooxygenase-1, -2, and p53. Landolfi, J.A., Terio, K.A. Vet. Pathol. (2006) [Pubmed]

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