Gene Review:
COX2 - cytochrome c oxidase subunit II
Felis catus
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High impact information on COX2
- Inhibition of thromboxane B2 production, measured by use of a radioimmunoassay, was taken as a marker of COX-1 and COX-2 activities [1].
- The S(+) enantiomeric form of carprofen was found to be COX-2 selective in cats, but meloxicam was only slightly preferential for this isoenzyme [1].
Associations of COX2 with chemical compounds
- PROCEDURE: COX-1 and COX-2 activities in heparinized whole blood samples were induced with calcium ionophore and lipopolysaccharide, respectively [1].
Other interactions of COX2
- The COX-1 and COX-2 assays were standardized, such that time courses of incubation with the test compounds and conditions of COX expression were as similar as possible in the 2 assays [1].
References
- Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats. Giraudel, J.M., Toutain, P.L., Lees, P. Am. J. Vet. Res. (2005) [Pubmed]
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