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Gene Review:

ILKAP - integrin-linked kinase-associated...

Homo sapiens

Synonyms: DKFZP434J2031, FLJ10181, ILKAP2, ILKAP3, Integrin-linked kinase-associated serine/threonine phosphatase 2C, ...

Tamura, S. et al., Kumar, A.S. et al., Leung-Hagesteijn, C. et al.

Tamura, Toriumi, Saito, Awano, Kudo, Kobayashi,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ILKAP

ILKAP, a protein serine/threonine (S/T) phosphatase of the PP2C family, was isolated in a yeast two-hybrid screen baited with integrin-linked kinase, ILK1 [1].
ILKAP regulates ILK signaling and inhibits anchorage-independent growth [2].
Silencing of endogenous ILKAP by short interfering RNA (siRNA) stimulated GSK3beta phosphorylation at S9, with no effect on PKB S473 phosphorylation [2].
The ILKAP-mediated inhibition of S9 phosphorylation was rescued by overexpression of ILK, but not by a dominant-negative ILK mutant [2].
In contrast, PP2Cdelta/ILKAP, a second PP2C family member, activates ASK1 by enhancing cellular phosphorylation of T845 [3].

Biological context of ILKAP

These observations raise the possibility that PP2Cdelta/ILKAP acts to control the cross-talk between integrin-induced and TNFalpha-induced signaling pathways, inhibiting the former and stimulating the latter, thereby inhibiting proliferation and survival and promoting the apoptosis of cancer cells [3].
PP2Cdelta/ILKAP also forms a complex with ILK1 to inhibit the GSK3beta-mediated integrin-ILK1 signaling in vivo, inhibiting cell cycle progression [3].

References

Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1. Leung-Hagesteijn, C., Mahendra, A., Naruszewicz, I., Hannigan, G.E. EMBO J. (2001) [Pubmed]
ILKAP regulates ILK signaling and inhibits anchorage-independent growth. Kumar, A.S., Naruszewicz, I., Wang, P., Leung-Hagesteijn, C., Hannigan, G.E. Oncogene (2004) [Pubmed]
PP2C family members play key roles in regulation of cell survival and apoptosis. Tamura, S., Toriumi, S., Saito, J., Awano, K., Kudo, T.A., Kobayashi, T. Cancer Sci. (2006) [Pubmed]

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AT1G18030	Arabidopsis thaliana
ILKAP	Bos taurus
F33A8.6	Caenorhabditis elegans
ILKAP	Canis lupus familiaris
zgc:162985	Danio rerio
ILKAP	Gallus gallus
ILKAP	Macaca mulatta
Ilkap	Mus musculus
Os09g0314400	Oryza sativa Japonica Group
ILKAP	Pan troglodytes
Ilkap	Rattus norvegicus
ilkap	Xenopus (Silurana) tropicalis

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