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Gene Review

ILKAP  -  integrin-linked kinase-associated...

Homo sapiens

Synonyms: DKFZP434J2031, FLJ10181, ILKAP2, ILKAP3, Integrin-linked kinase-associated serine/threonine phosphatase 2C, ...
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High impact information on ILKAP


Biological context of ILKAP

  • These observations raise the possibility that PP2Cdelta/ILKAP acts to control the cross-talk between integrin-induced and TNFalpha-induced signaling pathways, inhibiting the former and stimulating the latter, thereby inhibiting proliferation and survival and promoting the apoptosis of cancer cells [3].
  • PP2Cdelta/ILKAP also forms a complex with ILK1 to inhibit the GSK3beta-mediated integrin-ILK1 signaling in vivo, inhibiting cell cycle progression [3].


  1. Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1. Leung-Hagesteijn, C., Mahendra, A., Naruszewicz, I., Hannigan, G.E. EMBO J. (2001) [Pubmed]
  2. ILKAP regulates ILK signaling and inhibits anchorage-independent growth. Kumar, A.S., Naruszewicz, I., Wang, P., Leung-Hagesteijn, C., Hannigan, G.E. Oncogene (2004) [Pubmed]
  3. PP2C family members play key roles in regulation of cell survival and apoptosis. Tamura, S., Toriumi, S., Saito, J., Awano, K., Kudo, T.A., Kobayashi, T. Cancer Sci. (2006) [Pubmed]
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