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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ALX1  -  ALX homeobox 1

Homo sapiens

Synonyms: ALX homeobox protein 1, CART-1, CART1, Cartilage homeoprotein 1, FND3, ...
 
 
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Disease relevance of CART1

 

High impact information on CART1

  • AGI-1067 also improved luminal dimensions of the reference segments in the PCI vessels in CART-1, an effect that suggests a direct antiatherosclerosis effect [2].
  • Considering that oxidative stress and inflammation may persist for a prolonged period after stenting, treatment with AGI-1067 for the entire period of risk after PCI (instead of only 4 weeks in CART-1) may result in enhanced protection against luminal renarrowing in the ongoing multicenter CART-2 trial [2].
  • In the Canadian Antioxidant Restenosis Trial (CART-1) of AGI-1067 in percutaneous coronary interventions, AGI-1067 had no effect on LDL-cholesterol but lowered HDL-cholesterol [3].
 

Associations of CART1 with chemical compounds

  • AGI-1067 improved luminal dimensions of the PCI site and reduced restenosis in the Canadian Antioxidant Restenosis Trial (CART-1) [2].

References

  1. Assessment of oxygen-consumption by use of reverse Fick-principle and indirect calorimetry in critically Ill patients. Schneeweiss, B., Druml, W., Graninger, W., Grimm, G., Kleinberger, G., Lenz, K., Laggner, A. Clinical nutrition (Edinburgh, Scotland) (1989) [Pubmed]
  2. Clinical results with AGI-1067: a novel antioxidant vascular protectant. Tardif, J.C. Am. J. Cardiol. (2003) [Pubmed]
  3. Experimental and clinical studies show that the probucol derivative AGI-1067 prevents vascular growth. Doggrell, S.A. Expert opinion on investigational drugs. (2003) [Pubmed]
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