Gene Review:
Itga7 - integrin, alpha 7
Rattus norvegicus
Synonyms:
H36-alpha7, Integrin alpha-7
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High impact information on Itga7
- Immunoblots and immunofluorescence demonstrate that the H36-alpha 7 chain is associated with integrin beta 1 [1].
- H36-alpha 7 mRNA is present in replicating myoblasts: expression increases upon terminal differentiation and is markedly reduced in developmentally defective myoblasts [1].
- We conclude that H36-alpha 7 is a novel alpha integrin laminin binding protein whose expression is developmentally regulated during skeletal myogenesis [1].
Analytical, diagnostic and therapeutic context of Itga7
- Affinity chromatography demonstrates that H36-alpha 7 beta 1 selectively binds to laminin [1].
- Northern blots demonstrate that expression of H36-alpha 7 mRNA is regulated both early in the development of the myogenic lineage and later, during terminal differentiation [1].
References
- H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis. Song, W.K., Wang, W., Foster, R.F., Bielser, D.A., Kaufman, S.J. J. Cell Biol. (1992) [Pubmed]
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