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Gene Review

Itga7  -  integrin alpha 7

Mus musculus

Synonyms: Integrin alpha-7, alpha7
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Disease relevance of Itga7


Psychiatry related information on Itga7

  • The presence of alpha 7* nicotinic receptors on cholinergic neurones may also render these cells specifically vulnerable to degeneration in Alzheimer's disease [4].
  • The compounds were evaluated for binding to the alpha4beta2 and alpha7 nicotinic acetylcholine receptors (nAChRs), for pharmacological activity in the mouse tail-flick and hot-plate assays, and for hypothermia and locomotor activity [5].
  • MATERIALS AND METHODS: Mice with targeted deletion of the gene coding for the alpha7 subunit of nicotinic receptors and wild-type controls were trained on a five-choice serial reaction time task with food reinforcers presented under varying parametric conditions [6].
  • In the present study, we tested whether (-)-nicotine and U-50,488H prevent delayed-memory impairment induced by beta-amyloid peptide (25-35), and changes of expression of alpha7-type nicotinic acetylcholine receptor mRNA and prodynorphin mRNA [7].

High impact information on Itga7


Chemical compound and disease context of Itga7

  • Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease [10].
  • In vivo, methyllycaconitine (MLA), a specific alpha-7 nAChR antagonist, significantly prevented MDMA-induced neurotoxicity at dopaminergic but not at serotonergic level, without affecting MDMA-induced hyperthermia [11].
  • In behavioral experiments, intrathecal (i.t.) injection of non-selective nAChR antagonist mecamylamine and alpha4beta2 subtype-selective antagonist dihydro-beta-erythroidine (DHbetaE) dose-dependently induced thermal and mechanical hyperalgesia in mice while the alpha7-selective antagonist methyllycaconitine (MLA) had no effect [12].

Biological context of Itga7

  • The binding of Epibatidine and alphaBungarotoxin, ligands for alpha3- and alpha7-containing receptors, respectively, revealed, for each ligand, a single class of high-affinity binding sites, with similar affinity in both wild-type and mdx mice [13].
  • Expression of the laminin-binding alpha7 integrin is tightly regulated during myogenic differentiation, reflecting required functions that range from cell motility to formation of stable myotendinous junctions [14].
  • Functional analysis with site-specific deletions identified a specific double E-box sequence in the upstream promoter region (-2.0 to -2.6 kb) that is responsible for c-Myc-induced suppression of alpha7 expression [14].
  • This report provides evidence that alpha7 gene expression during muscle differentiation is regulated by the c-Myc transcription factor [14].
  • To ascertain whether integrin alpha7 upregulation compensates for the loss of the transmembrane sarcoglycan linkage in sarcoglycan-deficient muscle, we generated mice lacking both integrin alpha7 and gamma-sarcoglycan (gxi) [15].

Anatomical context of Itga7


Associations of Itga7 with chemical compounds


Regulatory relationships of Itga7


Other interactions of Itga7

  • Surprisingly, DKO mice survived post-natally and were indistinguishable from wild-type, integrin alpha7-deficient and mdx mice at birth, but died within 24-28 days [1].
  • The alpha 7 beta 1 laminin receptor was proposed to be involved in myogenic differentiation [19].
  • The N-terminal region of deltaEF1 is necessary for alpha7 repression, and this region also binds the co-activator p300/CBP [23].
  • Vinculin is present throughout development of the myotendinous junction, suggesting that the alpha 7 integrin recognizes a preformed cytoskeletal structure [24].
  • Conditioned dorsal root ganglia from normal mice cultured with a blocking antibody to beta1 integrin and from alpha7 integrin KO mice showed reduced axonal growth in both Matrigel- and laminin-supplemented collagen gels [25].

Analytical, diagnostic and therapeutic context of Itga7


  1. Absence of alpha7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy. Guo, C., Willem, M., Werner, A., Raivich, G., Emerson, M., Neyses, L., Mayer, U. Hum. Mol. Genet. (2006) [Pubmed]
  2. Expression of the alpha7beta1 laminin receptor suppresses melanoma growth and metastatic potential. Ziober, B.L., Chen, Y.Q., Ramos, D.M., Waleh, N., Kramer, R.H. Cell Growth Differ. (1999) [Pubmed]
  3. Role for the alpha7beta1 integrin in vascular development and integrity. Flintoff-Dye, N.L., Welser, J., Rooney, J., Scowen, P., Tamowski, S., Hatton, W., Burkin, D.J. Dev. Dyn. (2005) [Pubmed]
  4. Somato-dendritic nicotinic receptor responses recorded in vitro from the medial septal diagonal band complex of the rodent. Henderson, Z., Boros, A., Janzso, G., Westwood, A.J., Monyer, H., Halasy, K. J. Physiol. (Lond.) (2005) [Pubmed]
  5. Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues. Carroll, F.I., Brieaddy, L.E., Navarro, H.A., Damaj, M.I., Martin, B.R. J. Med. Chem. (2005) [Pubmed]
  6. Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task. Hoyle, E., Genn, R.F., Fernandes, C., Stolerman, I.P. Psychopharmacology (Berl.) (2006) [Pubmed]
  7. Alpha 7-type nicotinic acetylcholine receptor and prodynorphin mRNA expression after administration of (-)-nicotine and U-50,488H in beta-amyloid peptide (25-35)-treated mice. Hiramatsu, M., Watanabe, M., Baba, S., Kojima, R., Nabeshima, T. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  8. Absence of integrin alpha 7 causes a novel form of muscular dystrophy. Mayer, U., Saher, G., Fässler, R., Bornemann, A., Echtermeyer, F., von der Mark, H., Miosge, N., Pöschl, E., von der Mark, K. Nat. Genet. (1997) [Pubmed]
  9. Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. Huston, J.M., Ochani, M., Rosas-Ballina, M., Liao, H., Ochani, K., Pavlov, V.A., Gallowitsch-Puerta, M., Ashok, M., Czura, C.J., Foxwell, B., Tracey, K.J., Ulloa, L. J. Exp. Med. (2006) [Pubmed]
  10. Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease. Martin-Ruiz, C.M., Court, J.A., Molnar, E., Lee, M., Gotti, C., Mamalaki, A., Tsouloufis, T., Tzartos, S., Ballard, C., Perry, R.H., Perry, E.K. J. Neurochem. (1999) [Pubmed]
  11. Protection against MDMA-induced dopaminergic neurotoxicity in mice by methyllycaconitine: Involvement of nicotinic receptors. Chipana, C., Camarasa, J., Pubill, D., Escubedo, E. Neuropharmacology (2006) [Pubmed]
  12. Tonic inhibitory role of alpha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice. Rashid, M.H., Furue, H., Yoshimura, M., Ueda, H. Pain (2006) [Pubmed]
  13. Dystrophin stabilizes alpha 3- but not alpha 7-containing nicotinic acetylcholine receptor subtypes at the postsynaptic apparatus in the mouse superior cervical ganglion. Del Signore, A., Gotti, C., De Stefano, M.E., Moretti, M., Paggi, P. Neurobiol. Dis. (2002) [Pubmed]
  14. Regulation of alpha7 integrin expression during muscle differentiation. Xiao, J., Jethanandani, P., Ziober, B.L., Kramer, R.H. J. Biol. Chem. (2003) [Pubmed]
  15. Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscle. Allikian, M.J., Hack, A.A., Mewborn, S., Mayer, U., McNally, E.M. J. Cell. Sci. (2004) [Pubmed]
  16. Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin. Rooney, J.E., Welser, J.V., Dechert, M.A., Flintoff-Dye, N.L., Kaufman, S.J., Burkin, D.J. J. Cell. Sci. (2006) [Pubmed]
  17. Altered expression of the alpha7beta1 integrin in human and murine muscular dystrophies. Hodges, B.L., Hayashi, Y.K., Nonaka, I., Wang, W., Arahata, K., Kaufman, S.J. J. Cell. Sci. (1997) [Pubmed]
  18. Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice. Burkin, D.J., Wallace, G.Q., Nicol, K.J., Kaufman, D.J., Kaufman, S.J. J. Cell Biol. (2001) [Pubmed]
  19. A new isoform of the laminin receptor integrin alpha 7 beta 1 is developmentally regulated in skeletal muscle. Collo, G., Starr, L., Quaranta, V. J. Biol. Chem. (1993) [Pubmed]
  20. Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. Liu, Q., Zhang, J., Zhu, H., Qin, C., Chen, Q., Zhao, B. FASEB J. (2007) [Pubmed]
  21. Processing of ADP-ribosylated integrin alpha 7 in skeletal muscle myotubes. Zolkiewska, A., Moss, J. J. Biol. Chem. (1995) [Pubmed]
  22. TGF-beta 1 regulates adhesion of mucosal mast cell homologues to laminin-1 through expression of integrin alpha 7. Rosbottom, A., Scudamore, C.L., von der Mark, H., Thornton, E.M., Wright, S.H., Miller, H.R. J. Immunol. (2002) [Pubmed]
  23. Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis. Jethanandani, P., Kramer, R.H. J. Biol. Chem. (2005) [Pubmed]
  24. Alpha 7 beta 1 integrin is a component of the myotendinous junction on skeletal muscle. Bao, Z.Z., Lakonishok, M., Kaufman, S., Horwitz, A.F. J. Cell. Sci. (1993) [Pubmed]
  25. Involvement of alpha7beta1 integrin in the conditioning-lesion effect on sensory axon regeneration. Ekström, P.A., Mayer, U., Panjwani, A., Pountney, D., Pizzey, J., Tonge, D.A. Mol. Cell. Neurosci. (2003) [Pubmed]
  26. Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development. Ziober, B.L., Vu, M.P., Waleh, N., Crawford, J., Lin, C.S., Kramer, R.H. J. Biol. Chem. (1993) [Pubmed]
  27. Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor. Yao, C.C., Ziober, B.L., Sutherland, A.E., Mendrick, D.L., Kramer, R.H. J. Cell. Sci. (1996) [Pubmed]
  28. Distinct alpha 7A beta 1 and alpha 7B beta 1 integrin expression patterns during mouse development: alpha 7A is restricted to skeletal muscle but alpha 7B is expressed in striated muscle, vasculature, and nervous system. Velling, T., Collo, G., Sorokin, L., Durbeej, M., Zhang, H., Gullberg, D. Dev. Dyn. (1996) [Pubmed]
  29. Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle. Babbitt, C.J., Shai, S.Y., Harpf, A.E., Pham, C.G., Ross, R.S. Histochem. Cell Biol. (2002) [Pubmed]
  30. Impaired axonal regeneration in alpha7 integrin-deficient mice. Werner, A., Willem, M., Jones, L.L., Kreutzberg, G.W., Mayer, U., Raivich, G. J. Neurosci. (2000) [Pubmed]
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