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Gene Review

CLPTM1L  -  CLPTM1-like

Homo sapiens

Synonyms: CLPTM1-like protein, CRR9, CRR9p, Cisplatin resistance-related protein 9, Cleft lip and palate transmembrane protein 1-like protein, ...
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High impact information on CLPTM1L

  • Firefly and Renilla luciferases were used to monitor transcription from the hTERT and hCRR9 promoters, respectively [1].
  • A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis [2].
  • OS2 showed high expression of CRR9, low expression of Pgp, gammaGCS and MRP1, and no expression of V-ATPase [3].

Anatomical context of CLPTM1L

  • Hence, we have examined the chromatin structure of the native hTERT locus and the neighboring loci, CRR9 and Xtrp2, in normal human fibroblasts and a set of immortal lines [4].
  • In mouse embryonic stem cells stably integrated with the BAC reporter, both hTERT and hCRR9 promoters were highly expressed [1].


  1. Transcriptional Silencing of a Novel hTERT Reporter Locus during In Vitro Differentiation of Mouse Embryonic Stem Cells. Wang, S., Hu, C., Zhu, J. Mol. Biol. Cell (2007) [Pubmed]
  2. A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. Yamamoto, K., Okamoto, A., Isonishi, S., Ochiai, K., Ohtake, Y. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  3. Relationship between expression of drug-resistance factors and drug sensitivity in normal human renal proximal tubular epithelial cells in comparison with renal cell carcinoma. Asakura, T., Imai, A., Ohkubo-Uraoka, N., Kuroda, M., Iidaka, Y., Uchida, K., Shibasaki, T., Ohkawa, K. Oncol. Rep. (2005) [Pubmed]
  4. The hTERT gene is embedded in a nuclease-resistant chromatin domain. Wang, S., Zhu, J. J. Biol. Chem. (2004) [Pubmed]
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