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PF10_0344  -  glutamate-rich protein

Plasmodium falciparum 3D7

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High impact information on PF10_0344

  • The goal of this study was to evaluate the antibody response induced by Plasmodium falciparum glutamate-rich protein (GLURP) in naturally exposed individuals from the Brazilian Amazon region (Rondonia State) [1].
  • MSP1, MSP3, and glutamate-rich protein genotypes were also determined from a smaller group of samples, and all results were combined to derive an extended antigenic haplotype [2].
  • Genetic variation of the glutamate-rich protein (GLURP) of Plasmodium falciparum was analysed in 29 field isolates and 15 laboratory lines of diverse geographical origin, by DNA sequencing of the non-repetitive 5'-region (R0) of the glurp gene [3].
  • Using peptide specific antibodies, the amino termini of the 307 and 300 kDa forms have been mapped to between aa 477-487 and aa 523-555, respectively, which is the region between the glutamate rich repeats and the cysteine motif domains [4].
  • A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined [5].

Biological context of PF10_0344


Other interactions of PF10_0344


Analytical, diagnostic and therapeutic context of PF10_0344


  1. Antibody response profiles induced by Plasmodium falciparum glutamate-rich protein in naturally exposed individuals from a Brazilian area endemic for malaria. Pratt-Riccio, L.R., Lima-Junior, J.C., Carvalho, L.J., Theisen, M., Espíndola-Mendes, E.C., Santos, F., Oliveira-Ferreira, J., Goldberg, A.C., Daniel-Ribeiro, C.T., Banic, D.M. Am. J. Trop. Med. Hyg. (2005) [Pubmed]
  2. Alterations in Plasmodium falciparum genotypes during sequential infections suggest the presence of strain specific immunity. Eisen, D.P., Saul, A., Fryauff, D.J., Reeder, J.C., Coppel, R.L. Am. J. Trop. Med. Hyg. (2002) [Pubmed]
  3. Conservation and heterogeneity of the glutamate-rich protein (GLURP) among field isolates and laboratory lines of Plasmodium falciparum. de Stricker, K., Vuust, J., Jepsen, S., Oeuvray, C., Theisen, M. Mol. Biochem. Parasitol. (2000) [Pubmed]
  4. Proteolysis of Plasmodium falciparum surface antigen, Pfs230, during gametogenesis. Brooks, S.R., Williamson, K.C. Mol. Biochem. Parasitol. (2000) [Pubmed]
  5. Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle. Borre, M.B., Dziegiel, M., Høgh, B., Petersen, E., Rieneck, K., Riley, E., Meis, J.F., Aikawa, M., Nakamura, K., Harada, M. Mol. Biochem. Parasitol. (1991) [Pubmed]
  6. Characterization of a Plasmodium chabaudi gene encoding a protein with glutamate-rich tandem repeats. Giraldo, L.E., Jennings, G.J., Deleersnijder, W., Hamers-Casterman, C., Wiser, M.F. Parasitol. Res. (1999) [Pubmed]
  7. Immunization of Saimiri sciureus monkeys with a recombinant hybrid protein derived from the Plasmodium falciparum antigen glutamate-rich protein and merozoite surface protein 3 can induce partial protection with Freund and Montanide ISA720 adjuvants. Carvalho, L.J., Alves, F.A., Bianco, C., Oliveira, S.G., Zanini, G.M., Soe, S., Druilhe, P., Theisen, M., Muniz, J.A., Daniel-Ribeiro, C.T. Clin. Diagn. Lab. Immunol. (2005) [Pubmed]
  8. Sequence analysis and genotypes of glutamate rich protein of Plasmodium falciparum isolates from different malaria endemic areas in China. Zhu, X.P., Zhang, X.M., Zhou, L., Yang, Y.P., Gao, X. Biomed. Environ. Sci. (2002) [Pubmed]
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