Gene Review:
tyms - thymidylate synthetase
Danio rerio
Synonyms:
SO:0000704, zgc:56465, zgc:77659
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Disease relevance of tyms
- The zebrafish TS protein was expressed in Escherichia coli and purified to homogeneity [1].
High impact information on tyms
- To study the function of TS in zebrafish embryo development, a short hairpin RNA (shRNA) expression vector, pSilencer 4.1-CMV/TS, was constructed which targeted the protein-coding region of zebrafish TS mRNA [1].
- The deduced amino acid sequence of zebrafish TS was similar to those from other organisms, including rat, mouse and humans [1].
Biological context of tyms
- The open reading frame (ORF) of zebrafish TS cDNA sequence was 954 nucleotides, encoding a 318-amino acid protein with a calculated molecular mass of 36.15 kDa [1].
Analytical, diagnostic and therapeutic context of tyms
- Western immunoblot assay confirmed that TS was expressed in all the developmental stages of zebrafish with a high level of expression at the 1-4 cell stages [1].
- Sequence analysis and functional study of thymidylate synthase from zebrafish, Danio rerio [1].
- In order to use zebrafish as an animal model for screening novel anticancer agents, we isolated TS cDNA from zebrafish and compared its sequence with those from other species [1].
References
- Sequence analysis and functional study of thymidylate synthase from zebrafish, Danio rerio. Du, C., Niu, R., Chu, E., Zhang, P., Lin, X. J. Biochem. (2006) [Pubmed]
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