Gene Review:
Tyms - thymidylate synthase
Mus musculus
Synonyms:
TS, TSase, Thymidylate synthase
- Isolation and expression of rat thymidylate synthase cDNA: phylogenetic comparison with human and mouse thymidylate synthases. Cieśla, J., Weiner, K.X., Weiner, R.S., Reston, J.T., Maley, G.F., Maley, F. Biochim. Biophys. Acta (1995)
- Genomic organization, chromosomal localization, and expression of the murine thromboxane synthase gene. Zhang, L., Xiao, H., Schultz, R.A., Shen, R.F. Genomics (1997)
- Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency. Houghton, P.J., Germain, G.S., Hazelton, B.J., Pennington, J.W., Houghton, J.A. Proc. Natl. Acad. Sci. U.S.A. (1989)
- The 5'-flanking region of the mouse thymidylate synthase gene is necessary but not sufficient for normal regulation in growth-stimulated cells. Li, Y., Li, D., Osborn, K., Johnson, L.F. Mol. Cell. Biol. (1991)
- Inhibition of the mammalian transcription factor LSF induces S-phase-dependent apoptosis by downregulating thymidylate synthase expression. Powell, C.M., Rudge, T.L., Zhu, Q., Johnson, L.F., Hansen, U. EMBO J. (2000)
- A cell cycle analysis of growth-related genes expressed during T lymphocyte maturation. Feder, J.N., Guidos, C.J., Kusler, B., Carswell, C., Lewis, D., Schimke, R.T. J. Cell Biol. (1990)
- Influence of dose of [6RS]leucovorin on reduced folate pools and 5-fluorouracil-mediated thymidylate synthase inhibition in human colon adenocarcinoma xenografts. Houghton, J.A., Williams, L.G., Cheshire, P.J., Wainer, I.W., Jadaud, P., Houghton, P.J. Cancer Res. (1990)
- Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors. Rafi, I., Boddy, A.V., Calvete, J.A., Taylor, G.A., Newell, D.R., Bailey, N.P., Lind, M.J., Green, M., Hines, J., Johnstone, A., Clendeninn, N., Calvert, A.H. J. Clin. Oncol. (1998)
- Enhanced antitumor activity for the thymidylate synthase inhibitor 1843U89 through decreased host toxicity with oral folic acid. Smith, G.K., Amyx, H., Boytos, C.M., Duch, D.S., Ferone, R., Wilson, H.R. Cancer Res. (1995)
- Characterization of the pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in xenografts of human colon adenocarcinoma. Houghton, J.A., Williams, L.G., Radparvar, S., Houghton, P.J. Cancer Res. (1988)
- Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. Bruni, P., Minopoli, G., Brancaccio, T., Napolitano, M., Faraonio, R., Zambrano, N., Hansen, U., Russo, T. J. Biol. Chem. (2002)
- Sequence of a cDNA for mouse thymidylate synthase reveals striking similarity with the prokaryotic enzyme. Perryman, S.M., Rossana, C., Deng, T.L., Vanin, E.F., Johnson, L.F. Mol. Biol. Evol. (1986)
- Synergistic activation of the TATA-less mouse thymidylate synthase promoter by the Ets transcription factor GABP and Sp1. Rudge, T.L., Johnson, L.F. Exp. Cell Res. (2002)
- Mouse thymidylate synthase messenger RNA lacks a 3' untranslated region. Jenh, C.H., Deng, T.L., Li, D.W., DeWille, J., Johnson, L.F. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Splicing signals are required for S-phase regulation of the mouse thymidylate synthase gene. Ke, Y., Ash, J., Johnson, L.F. Mol. Cell. Biol. (1996)
- Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography. Perumal, M., Pillai, R.G., Barthel, H., Leyton, J., Latigo, J.R., Forster, M., Mitchell, F., Jackman, A.L., Aboagye, E.O. Cancer Res. (2006)
- Molecular cloning of DNA sequences complementary to mouse thymidylate synthase messenger RNA. Geyer, P.K., Johnson, L.F. J. Biol. Chem. (1984)
- Cloning and characterization of the promoter region of monkey thymidylate synthase gene. Horie, N., Wakabayashi, M., Katai, H., Takeishi, K. Biol. Pharm. Bull. (1998)
- Identification of functional elements in the promoter region of the human gene for thymidylate synthase and nuclear factors that regulate the expression of the gene. Horie, N., Takeishi, K. J. Biol. Chem. (1997)
- Introns are essential for growth-regulated expression of the mouse thymidylate synthase gene. Ash, J., Ke, Y., Korb, M., Johnson, L.F. Mol. Cell. Biol. (1993)
- Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition. Seither, R.L., Trent, D.F., Mikulecky, D.C., Rape, T.J., Goldman, I.D. J. Biol. Chem. (1991)
- Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines. Jenh, C.H., Geyer, P.K., Baskin, F., Johnson, L.F. Mol. Pharmacol. (1985)
- Insulin-like growth factor I regulation of transcription and replicating enzyme induction necessary for DNA synthesis. Yang, H.C., Pardee, A.B. J. Cell. Physiol. (1986)
- Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Almasan, A., Yin, Y., Kelly, R.E., Lee, E.Y., Bradley, A., Li, W., Bertino, J.R., Wahl, G.M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model. Seitz, U., Wagner, M., Vogg, A.T., Glatting, G., Neumaier, B., Greten, F.R., Schmid, R.M., Reske, S.N. Cancer Res. (2001)
- A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes. Liao, Z.Y., Sordet, O., Zhang, H.L., Kohlhagen, G., Antony, S., Gmeiner, W.H., Pommier, Y. Cancer Res. (2005)
- Inhibition of mouse thymidylate synthase promoter activity by the wild-type p53 tumor suppressor protein. Lee, Y., Chen, Y., Chang, L.S., Johnson, L.F. Exp. Cell Res. (1997)
- The mouse thymidylate synthase promoter: essential elements are in close proximity to the transcriptional initiation sites. Deng, T., Li, Y., Jolliff, K., Johnson, L.F. Mol. Cell. Biol. (1989)
- Construction and expression of mouse thymidylate synthase minigenes. DeWille, J.W., Jenh, C.H., Deng, T., Harendza, C.J., Johnson, L.F. J. Biol. Chem. (1988)