Gene Review:
Tyms - thymidylate synthetase
Rattus norvegicus
Synonyms:
TS, TSase, Thymidylate synthase
- Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug. Sotelo-Mundo, R.R., Ciesla, J., Dzik, J.M., Rode, W., Maley, F., Maley, G.F., Hardy, L.W., Montfort, W.R. Biochemistry (1999)
- Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer. Park, D.J., Stoehlmacher, J., Zhang, W., Tsao-Wei, D., Groshen, S., Lenz, H.J. International journal of colorectal disease. (2002)
- Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products. Zerler, B., Roberts, R.J., Mathews, M.B., Moran, E. Mol. Cell. Biol. (1987)
- The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase. Galivan, J., Rhee, M.S., Johnson, T.B., Dilwith, R., Nair, M.G., Bunni, M., Priest, D.G. J. Biol. Chem. (1989)
- Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency. Jones, T.R., Thornton, T.J., Flinn, A., Jackman, A.L., Newell, D.R., Calvert, A.H. J. Med. Chem. (1989)
- Stable transfection of malaria parasite blood stages. van Dijk, M.R., Waters, A.P., Janse, C.J. Science (1995)
- Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine. Galivan, J., Nimec, Z., Rhee, M. Cancer Res. (1987)
- Persistent induction of apoptosis and suppression of mitosis as the basis for curative therapy with S-1, an oral 5-fluorouracil prodrug in a colorectal tumor model. Cao, S., Lu, K., Tóth, K., Slocum, H.K., Shirasaka, T., Rustum, Y.M. Clin. Cancer Res. (1999)
- Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells. Rhee, M.S., Galivan, J., Wright, J.E., Rosowsky, A. Mol. Pharmacol. (1994)
- Relative activities of thymidylate synthetase and thymidine kinase in 1,2-dimethylhydrazine-induced colon carcinomas in rats. Sakamoto, S., Kuwa, K., Tsukada, K., Sagara, T., Kasahara, N., Okamoto, R. Carcinogenesis (1987)
- The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat. van der Wilt, C.L., Marinelli, A., Pinedo, H.M., Cloos, J., Smid, K., van de Velde, C.J., Peters, G.J. Eur. J. Cancer (1995)
- Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma. Berne, M.H., Gustavsson, B.G., Almersjö, O., Spears, P.C., Frösing, R. Cancer Chemother. Pharmacol. (1986)
- Biologically based dose-response modeling in developmental toxicology: biochemical and cellular sequelae of 5-fluorouracil exposure in the developing rat. Shuey, D.L., Lau, C., Logsdon, T.R., Zucker, R.M., Elstein, K.H., Narotsky, M.G., Setzer, R.W., Kavlock, R.J., Rogers, J.M. Toxicol. Appl. Pharmacol. (1994)
- Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model. Hu, M., Roland, K., Ge, L., Chen, J., Li, Y., Tyle, P., Roy, S. Journal of pharmaceutical sciences. (1998)
- Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat. Berne, M., Gustavsson, B., Almersjö, O., Spears, P., Sundström, E. Cancer Invest. (1988)
- Prediction of antifolate efficacy in a rat sarcoma model. Li, W.W., Lin, J.T., Chang, Y.M., Schweitzer, B., Bertino, J.R. Int. J. Cancer (1991)
- Nucleosides. 150. Synthesis and some biological properties of 5-monofluoromethyl, 5-difluoromethyl, and 5-trifluoromethyl derivatives of 2'-deoxyuridine and 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyluracil. Matulic-Adamic, J., Takahashi, K., Chou, T.C., Gadler, H., Price, R.W., Reddy, A.R., Kalman, T.I., Watanabe, K.A. J. Med. Chem. (1988)
- Effects of macrophage- and granulocyte-colony stimulating factors on thymidylate synthase and thymidine kinase activity in rat hematopoietic cells. Kudo, H., Suzuki, S., Kuwa, K., Nakayama, T., Maemura, M., Sakamoto, S. Haematologica (1997)
- Pyrimidine metabolism during restorative brain growth after neonatal undernutrition in the rat. Weichsel, M.E., Clark, B.R. Pediatr. Res. (1977)
- An isotopic assay of dUTPase activity based on coupling with thymidylate synthase. Gołos, B., Rode, W. Acta Biochim. Pol. (1999)
- Inhibition of thymidylate synthase and thymidine kinase by okadaic acid in regenerating rat liver after partial hepatectomy. Tsukamoto, I., Yoshida, Y., Kitamura, Y., Nomura, S. Biochem. Pharmacol. (1996)
- Latent Pneumocystis carinii infection in commercial rat colonies: comparison of inductive immunosuppressants plus histopathology, PCR, and serology as detection methods. Weisbroth, S.H., Geistfeld, J., Weisbroth, S.P., Williams, B., Feldman, S.H., Linke, M.J., Orr, S., Cushion, M.T. J. Clin. Microbiol. (1999)