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Gene Review:

BRK1 - protein BRICK 1

Arabidopsis thaliana

Synonyms: ATBRK1, BRICK1, HSPC300, T9I22.8, T9I22_8

Frank, M.J. et al., Djakovic, S. et al., Frank, M. et al., Zimmermann, I. et al.

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High impact information on BRK1/HSPC300

Thus, AtSCAR proteins are likely to function in association with AtBRK1, and perhaps other Arabidopsis homologs of WAVE complex components, to regulate activation of the Arp2,3 complex in vivo [1].
Analysis of double mutants provides genetic evidence that BRK1 functions in a pathway with the ARP2/3 complex [2].
Essential roles in WAVE complex assembly or function have been demonstrated for PIR121/Sra-1, Nap1 and Abi-2, but the significance of HSPC300 in this complex is unclear [2].
In expanding brk1 epidermal cells, microtubule organization differs little from that in wild-type, but localized enrichments of cortical F-actin seen at the tips of emerging lobes in wild-type cells fail to form [3].
These observations suggest a critical role for F-actin in lobe formation and together with additional effects of brk1 on the morphogenesis of stomata and hairs suggest that Brk1 promotes multiple, actin-dependent cell polarization events in the developing leaf epidermis [3].

Biological context of BRK1/HSPC300

BRICK1/HSPC300 functions with SCAR and the ARP2/3 complex to regulate epidermal cell shape in Arabidopsis [2].
As an HSPC300 homolog is present in the Arabidopsis genome but no WAVE homolog has yet been found, the existence of a related regulation pathway was doubtful [4].

References

Activation of Arp2/3 complex-dependent actin polymerization by plant proteins distantly related to Scar/WAVE. Frank, M., Egile, C., Dyachok, J., Djakovic, S., Nolasco, M., Li, R., Smith, L.G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
BRICK1/HSPC300 functions with SCAR and the ARP2/3 complex to regulate epidermal cell shape in Arabidopsis. Djakovic, S., Dyachok, J., Burke, M., Frank, M.J., Smith, L.G. Development (2006) [Pubmed]
A small, novel protein highly conserved in plants and animals promotes the polarized growth and division of maize leaf epidermal cells. Frank, M.J., Smith, L.G. Curr. Biol. (2002) [Pubmed]
The Arabidopsis GNARLED gene encodes the NAP125 homolog and controls several actin-based cell shape changes. Zimmermann, I., Saedler, R., Mutondo, M., Hulskamp, M. Mol. Genet. Genomics (2004) [Pubmed]

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