The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

VAR2  -  ATP-dependent zinc metalloprotease FTSH 2

Arabidopsis thaliana

Synonyms: F7F1.16, F7F1_16, FTSH2, VARIEGATED 2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on VAR2

  • The majority of VAR1 appears to exist as heterocomplexes with VAR2, whereas VAR2 may be present as homocomplexes as well [1].
  • Overexpression of AtFtsH1, but not AtFtsH2/VAR2, normalizes the pattern of var1 variegation, restoring a nonvariegated phenotype [2].
  • Both mechanisms emphasize compensating activities and the notion of plastid autonomy, but redundant gene products are proposed to play a role in var2, but not in im [3].
  • The yellow variegated mutant of Arabidopsis is plastid autonomous and delayed in chloroplast biogenesis [4].
  • We suggest that the stochastic pattern of variegation in the mutant may be due to an interplay of factors that regulate var2 gene expression and factors that mediate rates of cell and plastid division [4].

Anatomical context of VAR2

  • This finding suggests that VAR1 and VAR2 play a predominant role in the photosystem II repair cycle in thylakoid membranes [1].
  • Based on these results, we conclude that VAR1 and VAR2 are the major components of an FtsH complex involved in the repair of photodamaged proteins in thylakoid membranes [1].
  • The VAR2 locus has been shown to encode a chloroplastic FtsH, an ATP-dependent protease which is possibly involved in the degradation of thylakoid proteins and plastid development [5].

Other interactions of VAR2

  • These observations led us to examine whether VAR1 and VAR2 form a complex [1].


  1. Coordinated regulation and complex formation of yellow variegated1 and yellow variegated2, chloroplastic FtsH metalloproteases involved in the repair cycle of photosystem II in Arabidopsis thylakoid membranes. Sakamoto, W., Zaltsman, A., Adam, Z., Takahashi, Y. Plant Cell (2003) [Pubmed]
  2. Functional redundancy of AtFtsH metalloproteases in thylakoid membrane complexes. Yu, F., Park, S., Rodermel, S.R. Plant Physiol. (2005) [Pubmed]
  3. Variegation mutants and mechanisms of chloroplast biogenesis. Yu, F., Fu, A., Aluru, M., Park, S., Xu, Y., Liu, H., Liu, X., Foudree, A., Nambogga, M., Rodermel, S. Plant Cell Environ. (2007) [Pubmed]
  4. The yellow variegated mutant of Arabidopsis is plastid autonomous and delayed in chloroplast biogenesis. Chen, M., Jensen, M., Rodermel, S. J. Hered. (1999) [Pubmed]
  5. The VAR1 locus of Arabidopsis encodes a chloroplastic FtsH and is responsible for leaf variegation in the mutant alleles. Sakamoto, W., Tamura, T., Hanba-Tomita, Y., Murata, M. Genes Cells (2002) [Pubmed]
WikiGenes - Universities