The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

VAR1  -  ATP-dependent zinc metalloprotease FTSH 5

Arabidopsis thaliana

Synonyms: FTSH5, K5J14.13, K5J14_13, VARIEGATED 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on VAR1


Biological context of VAR1


Anatomical context of VAR1


Associations of VAR1 with chemical compounds

  • Nineteen mutants displaying high levels of somatic Ac activity, as judged by their highly variegated phenotypes, were isolated after screening the M2 generation on streptomycin-containing medium [7].

Other interactions of VAR1

  • These observations led us to examine whether VAR1 and VAR2 form a complex [1].
  • The stable, recessive Arabidopsis variegated 3 (var3) mutant exhibits a variegated phenotype due to somatic areas lacking or containing developmentally retarded chloroplasts and greatly reduced numbers of palisade cells [8].
  • Nongreen sectors of variegated leaves lacking Thf1 expression contain plastids that accumulate membrane vesicles on the interior and lack organized thylakoid structures [9].


  1. Coordinated regulation and complex formation of yellow variegated1 and yellow variegated2, chloroplastic FtsH metalloproteases involved in the repair cycle of photosystem II in Arabidopsis thylakoid membranes. Sakamoto, W., Zaltsman, A., Adam, Z., Takahashi, Y. Plant Cell (2003) [Pubmed]
  2. Mutations in the Arabidopsis gene IMMUTANS cause a variegated phenotype by inactivating a chloroplast terminal oxidase associated with phytoene desaturation. Carol, P., Stevenson, D., Bisanz, C., Breitenbach, J., Sandmann, G., Mache, R., Coupland, G., Kuntz, M. Plant Cell (1999) [Pubmed]
  3. Mutations at the Arabidopsis CHM locus promote rearrangements of the mitochondrial genome. Martínez-Zapater, J.M., Gil, P., Capel, J., Somerville, C.R. Plant Cell (1992) [Pubmed]
  4. Genetics of homology-dependent gene silencing in Arabidopsis; a role for methylation. Davies, G.J., Sheikh, M.A., Ratcliffe, O.J., Coupland, G., Furner, I.J. Plant J. (1997) [Pubmed]
  5. The Arabidopsis immutans mutation affects plastid differentiation and the morphogenesis of white and green sectors in variegated plants. Aluru, M.R., Bae, H., Wu, D., Rodermel, S.R. Plant Physiol. (2001) [Pubmed]
  6. The VAR1 locus of Arabidopsis encodes a chloroplastic FtsH and is responsible for leaf variegation in the mutant alleles. Sakamoto, W., Tamura, T., Hanba-Tomita, Y., Murata, M. Genes Cells (2002) [Pubmed]
  7. Increased Ac excision (iae): Arabidopsis thaliana mutations affecting Ac transposition. Jarvis, P., Belzile, F., Page, T., Dean, C. Plant J. (1997) [Pubmed]
  8. Arabidopsis VARIEGATED 3 encodes a chloroplast-targeted, zinc-finger protein required for chloroplast and palisade cell development. Naested, H., Holm, A., Jenkins, T., Nielsen, H.B., Harris, C.A., Beale, M.H., Andersen, M., Mant, A., Scheller, H., Camara, B., Mattsson, O., Mundy, J. J. Cell. Sci. (2004) [Pubmed]
  9. Deletion of the chloroplast-localized Thylakoid formation1 gene product in Arabidopsis leads to deficient thylakoid formation and variegated leaves. Wang, Q., Sullivan, R.W., Kight, A., Henry, R.L., Huang, J., Jones, A.M., Korth, K.L. Plant Physiol. (2004) [Pubmed]
WikiGenes - Universities