High impact information on HOS1

• The Arabidopsis HOS1 gene negatively regulates cold signal transduction and encodes a RING finger protein that displays cold-regulated nucleo--cytoplasmic partitioning [1].
• Ectopic expression of HOS1 in wild-type plants causes cosuppression of HOS1 expression and mimics the hos1 mutant phenotypes [1].
• The hos1 mutant plants flower early, and this correlates with a low level of Flowering Locus C gene expression [1].
• HOS1, a genetic locus involved in cold-responsive gene expression in arabidopsis [2].
• HOS1 physically interacts with ICE1 and mediates the ubiquitination of ICE1 both in vitro and in vivo [3].

Other interactions of HOS1

• Our results indicate that cold stress responses in Arabidopsis are attenuated by a ubiquitination/proteasome pathway in which HOS1 mediates the degradation of the ICE1 protein [3].

Analytical, diagnostic and therapeutic context of HOS1

• Molecular cloning and characterization revealed that HOS1 encodes a ring finger protein, which has been implicated as an E3 ubiquitin conjugating enzyme [4].

References