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Gene Review:

ICE1 - transcription factor ICE1

Arabidopsis thaliana

Synonyms: ATICE1, INDUCER OF CBF EXPRESSION 1, SCREAM, SCRM

Chinnusamy, V. et al., Skinner, J.S. et al., Dong, C.H. et al.

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High impact information on ICE1

ICE1 binds specifically to the MYC recognition sequences in the CBF3 promoter [1].
ICE1 encodes a MYC-like bHLH transcriptional activator [1].
HOS1 physically interacts with ICE1 and mediates the ubiquitination of ICE1 both in vitro and in vivo [2].
We identified and assigned either linkage map or chromosome locations to 1 ICE1 homolog, 2 ZAT12 homologs, and 17 of 20 CBF homologs [3].

Biological context of ICE1

An Arabidopsis ice1 mutant was isolated in a screen for mutations that impair cold-induced transcription of a CBF3 promoter-luciferase reporter gene [1].
We investigated the allelic nature and map locations of Hordeum vulgare (barley) homologs to three classes of Arabidopsis low temperature (LT) regulatory genes-CBFs, ICE1, and ZAT12-to determine if there were any candidates for winterhardiness-related quantitative trait loci (QTL) [3].

Regulatory relationships of ICE1

The ice1 mutation blocks the expression of CBF3 and decreases the expression of many genes downstream of CBFs, which leads to a significant reduction in plant chilling and freezing tolerance [1].

Other interactions of ICE1

Our results indicate that cold stress responses in Arabidopsis are attenuated by a ubiquitination/proteasome pathway in which HOS1 mediates the degradation of the ICE1 protein [2].

References

ICE1: a regulator of cold-induced transcriptome and freezing tolerance in Arabidopsis. Chinnusamy, V., Ohta, M., Kanrar, S., Lee, B.H., Hong, X., Agarwal, M., Zhu, J.K. Genes Dev. (2003) [Pubmed]
The negative regulator of plant cold responses, HOS1, is a RING E3 ligase that mediates the ubiquitination and degradation of ICE1. Dong, C.H., Agarwal, M., Zhang, Y., Xie, Q., Zhu, J.K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Mapping of barley homologs to genes that regulate low temperature tolerance in Arabidopsis. Skinner, J.S., Szucs, P., von Zitzewitz, J., Marquez-Cedillo, L., Filichkin, T., Stockinger, E.J., Thomashow, M.F., Chen, T.H., Hayes, P.M. Theor. Appl. Genet. (2006) [Pubmed]

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