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Gene Review:

MSH1 - MUTL protein-like protein 1

Arabidopsis thaliana

Synonyms: ATMSH1, CHLOROPLAST MUTATOR, CHM, CHM1, MUTL protein homolog 1

Sakamoto, W. et al., Martínez-Zapater, J.M. et al., Sakamoto, W. et al., Abdelnoor, R.V. et al.

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Disease relevance of CHM

The CHM gene was shown to encode a protein related to the MutS protein of Escherichia coli that is involved in mismatch repair and DNA recombination [1].

High impact information on CHM

Thus, a mutation at the CHM locus affects mitochondrial gene expression, and impaired mitochondrial function may result in the distorted phenotype [2].
Altered mitochondrial gene expression in a maternal distorted leaf mutant of Arabidopsis induced by chloroplast mutator [2].
Mutations at the Arabidopsis CHM locus promote rearrangements of the mitochondrial genome [3].
Nuclear recessive mutations at the chloroplast mutator (CHM) locus of Arabidopsis produce a variegated phenotype that is inherited in a non-Mendelian fashion [3].
Properties of an unusual atp9-rpl16 cotranscript preferentially found in the maternal distorted leaf mutant of Arabidopsis thaliana, which had arisen from a genetic cross between chloroplast mutator and wild-type plants, were examined [4].

References

Substoichiometric shifting in the plant mitochondrial genome is influenced by a gene homologous to MutS. Abdelnoor, R.V., Yule, R., Elo, A., Christensen, A.C., Meyer-Gauen, G., Mackenzie, S.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Altered mitochondrial gene expression in a maternal distorted leaf mutant of Arabidopsis induced by chloroplast mutator. Sakamoto, W., Kondo, H., Murata, M., Motoyoshi, F. Plant Cell (1996) [Pubmed]
Mutations at the Arabidopsis CHM locus promote rearrangements of the mitochondrial genome. Martínez-Zapater, J.M., Gil, P., Capel, J., Somerville, C.R. Plant Cell (1992) [Pubmed]
An unusual mitochondrial atp9-rpl16 cotranscript found in the maternal distorted leaf mutant of Arabidopsis thaliana: implication of GUG as an initiation codon in plant mitochondria. Sakamoto, W., Tan, S.H., Murata, M., Motoyoshi, F. Plant Cell Physiol. (1997) [Pubmed]

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