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Gene Review

RHL41  -  high light responsive zinc finger protein...

Arabidopsis thaliana

Synonyms: AtZAT12, MMN10.11, MMN10_11, RESPONSIVE TO HIGH LIGHT 41, ZAT12
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Disease relevance of RHL41

  • Using Zat12 gain- and loss-of-function lines, we assign a function for Zat12 during oxidative, osmotic, salinity, high light, and heat stresses [1].

High impact information on RHL41


Biological context of RHL41

  • We propose that the RHL41 zinc finger protein has a key role in the acclimatization response to changes in light intensity [4].
  • Under specific growth conditions, Zat12 may therefore regulate a collection of transcripts involved in the response of Arabidopsis to high light and oxidative stress [1].
  • Thus, the large majority (92%) of the most highly induced genes belong to the CBF and ZAT12 regulons [3].
  • Using a fusion between the Zat12 promoter and the reporter gene luciferase, we demonstrate that Zat12 expression is activated at the transcriptional level during different abiotic stresses and in response to a wound-induced systemic signal [1].
  • Constitutive expression of ZAT12 in Arabidopsis caused a small, but reproducible, increase in freezing tolerance, indicating a role for the ZAT12 regulon in cold acclimation [3].

Associations of RHL41 with chemical compounds

  • Transcriptional profiling of Zat12-overexpressing plants and wild-type plants subjected to H(2)O(2) stress revealed that constitutive expression of Zat12 in Arabidopsis results in the enhanced expression of oxidative- and light stress-response transcripts [1].

Other interactions of RHL41

  • Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis [3].
  • In addition, the cold responsiveness of RAV1 and ZAT12, genes that are cold induced in parallel with CBF1-3, was also subject to circadian regulation [5].
  • We identified and assigned either linkage map or chromosome locations to 1 ICE1 homolog, 2 ZAT12 homologs, and 17 of 20 CBF homologs [6].


  1. The zinc-finger protein Zat12 plays a central role in reactive oxygen and abiotic stress signaling in Arabidopsis. Davletova, S., Schlauch, K., Coutu, J., Mittler, R. Plant Physiol. (2005) [Pubmed]
  2. The zinc finger protein Zat12 is required for cytosolic ascorbate peroxidase 1 expression during oxidative stress in Arabidopsis. Rizhsky, L., Davletova, S., Liang, H., Mittler, R. J. Biol. Chem. (2004) [Pubmed]
  3. Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis. Vogel, J.T., Zarka, D.G., Van Buskirk, H.A., Fowler, S.G., Thomashow, M.F. Plant J. (2005) [Pubmed]
  4. A zinc finger protein RHL41 mediates the light acclimatization response in Arabidopsis. Iida, A., Kazuoka, T., Torikai, S., Kikuchi, H., Oeda, K. Plant J. (2000) [Pubmed]
  5. Low temperature induction of Arabidopsis CBF1, 2, and 3 is gated by the circadian clock. Fowler, S.G., Cook, D., Thomashow, M.F. Plant Physiol. (2005) [Pubmed]
  6. Mapping of barley homologs to genes that regulate low temperature tolerance in Arabidopsis. Skinner, J.S., Szucs, P., von Zitzewitz, J., Marquez-Cedillo, L., Filichkin, T., Stockinger, E.J., Thomashow, M.F., Chen, T.H., Hayes, P.M. Theor. Appl. Genet. (2006) [Pubmed]
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