Disease relevance of RHL41

• Using Zat12 gain- and loss-of-function lines, we assign a function for Zat12 during oxidative, osmotic, salinity, high light, and heat stresses [1].

High impact information on RHL41

• The expression of Zat12, Zat7, and WRKY25 was simultaneously elevated in cells in response to oxidative stress (i.e. H(2)O(2) or paraquat application), heat shock, or wounding [2].
• The zinc finger protein Zat12 is required for cytosolic ascorbate peroxidase 1 expression during oxidative stress in Arabidopsis [2].
• Transgenic plants expressing Zat12 or Zat7 could tolerate oxidative stress [2].
• Zat12-deficient plants were also more sensitive than wild type plants to H(2)O(2) application as revealed by a higher level of H(2)O(2)-induced protein oxidation detected in these plants by protein blots [2].
• Of the 25 core cold-induced genes that were most highly upregulated (induced over 15-fold), 19 genes (84%) were induced by CBF2 and another two genes (8%) were regulated by both CBF2 and ZAT12 [3].

Biological context of RHL41

• We propose that the RHL41 zinc finger protein has a key role in the acclimatization response to changes in light intensity [4].
• Under specific growth conditions, Zat12 may therefore regulate a collection of transcripts involved in the response of Arabidopsis to high light and oxidative stress [1].
• Thus, the large majority (92%) of the most highly induced genes belong to the CBF and ZAT12 regulons [3].
• Using a fusion between the Zat12 promoter and the reporter gene luciferase, we demonstrate that Zat12 expression is activated at the transcriptional level during different abiotic stresses and in response to a wound-induced systemic signal [1].
• Constitutive expression of ZAT12 in Arabidopsis caused a small, but reproducible, increase in freezing tolerance, indicating a role for the ZAT12 regulon in cold acclimation [3].

Associations of RHL41 with chemical compounds

• Transcriptional profiling of Zat12-overexpressing plants and wild-type plants subjected to H(2)O(2) stress revealed that constitutive expression of Zat12 in Arabidopsis results in the enhanced expression of oxidative- and light stress-response transcripts [1].

Other interactions of RHL41

• Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis [3].
• In addition, the cold responsiveness of RAV1 and ZAT12, genes that are cold induced in parallel with CBF1-3, was also subject to circadian regulation [5].
• We identified and assigned either linkage map or chromosome locations to 1 ICE1 homolog, 2 ZAT12 homologs, and 17 of 20 CBF homologs [6].

References