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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NIT3  -  nitrilase 3

Arabidopsis thaliana

Synonyms: AtNIT3, NITRILASE 3
 
 
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High impact information on NIT3

  • NIT3 promoter activity was strongly induced by O-acetylserine, suggesting that, as is the case with enzymes of sulphate assimilation, sulphate deficiency may be communicated to NIT3 via an increase in the level of the cysteine precursor, O-acetylserine [1].
  • NIT2 was earlier shown to be highly expressed in developing and in mature A. thaliana embryos, and NIT3 is the dominantly active gene in the hypocotyl and the cotyledons of young, germinating seedlings [2].
  • While all nitrilases exhibit a similar pH optimum around neutral, and NIT1 and NIT3 exhibit a similar temperature optimum around 30 degrees C independent of the substrate analyzed (IAN, PPN), NIT2 showed a remarkably different temperature optimum for IAN (15 degrees C) and PPN (35-40 degrees C) [3].
  • A 13.8 kb DNA sequence containing the promoters and the structural genes of the Arabidopsis thaliana nit2/nit1/nit3 gene cluster has been isolated and characterized [4].
 

Biological context of NIT3

 

Other interactions of NIT3

  • Genomic Southern hybridization, among other experiments, strongly suggests that tobacco has NIT4 homologs but not NIT1 to NIT3 homologs [5].

References

  1. A role for nitrilase 3 in the regulation of root morphology in sulphur-starving Arabidopsis thaliana. Kutz, A., Müller, A., Hennig, P., Kaiser, W.M., Piotrowski, M., Weiler, E.W. Plant J. (2002) [Pubmed]
  2. Occurrence and formation of indole-3-acetamide in Arabidopsis thaliana. Pollmann, S., Müller, A., Piotrowski, M., Weiler, E.W. Planta (2002) [Pubmed]
  3. Enzymatic characterization of the recombinant Arabidopsis thaliana nitrilase subfamily encoded by the NIT2/NIT1/NIT3-gene cluster. Vorwerk, S., Biernacki, S., Hillebrand, H., Janzik, I., Müller, A., Weiler, E.W., Piotrowski, M. Planta (2001) [Pubmed]
  4. Structural analysis of the nit2/nit1/nit3 gene cluster encoding nitrilases, enzymes catalyzing the terminal activation step in indole-acetic acid biosynthesis in Arabidopsis thaliana. Hillebrand, H., Bartling, D., Weiler, E.W. Plant Mol. Biol. (1998) [Pubmed]
  5. Genes encoding nitrilase-like proteins from tobacco. Dohmoto, M., Tsunoda, H., Isaji, G., Chiba, R., Yamaguchi, K. DNA Res. (2000) [Pubmed]
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