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Gene Review

PAS1  -  peptidyl-prolyl isomerase PASTICCINO1

Arabidopsis thaliana

Synonyms: DEI1, PASTICCINO 1
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High impact information on PAS1

  • The expression of the PAS1 gene is increased in the presence of cytokinins, a class of phytohormones originally discovered because of their ability to stimulate cell division [1].
  • There are three complementation groups of pas mutants (pas1, pas2, and pas3, with, respectively 2, 1, and 4 alleles) [1].
  • We have isolated mutants pasticcino belonging to 3 complementation groups (pas1, pas2, pas3) in the progeny of independent ethyl methane sulfonate and T-DNA mutagenized Arabidopsis thaliana plants [2].
  • These two enzymes are responsible for PPIase activity in both soluble and membrane-associated fractions of thylakoid lumen suggesting that other lumenal immunophilins are not active towards the peptide substrates [3].
  • Profound redox-dependence of PPIase activity implies oxidative activation of protein folding catalysis under oxidative stress and photosynthetic oxygen production in the thylakoid lumen of plant chloroplasts [3].

Other interactions of PAS1

  • PAS2 expression was found in every plant organ and was not regulated by PAS1 and PAS3 genes [4].


  1. Mutation in the Arabidopsis PASTICCINO1 gene, which encodes a new FK506-binding protein-like protein, has a dramatic effect on plant development. Vittorioso, P., Cowling, R., Faure, J.D., Caboche, M., Bellini, C. Mol. Cell. Biol. (1998) [Pubmed]
  2. The PASTICCINO genes of Arabidopsis thaliana are involved in the control of cell division and differentiation. Faure, J.D., Vittorioso, P., Santoni, V., Fraisier, V., Prinsen, E., Barlier, I., Van Onckelen, H., Caboche, M., Bellini, C. Development (1998) [Pubmed]
  3. Profound redox sensitivity of peptidyl-prolyl isomerase activity in Arabidopsis thylakoid lumen. Shapiguzov, A., Edvardsson, A., Vener, A.V. FEBS Lett. (2006) [Pubmed]
  4. Pasticcino2 is a protein tyrosine phosphatase-like involved in cell proliferation and differentiation in Arabidopsis. Bellec, Y., Harrar, Y., Butaeye, C., Darnet, S., Bellini, C., Faure, J.D. Plant J. (2002) [Pubmed]
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