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Gene Review

ELI3-2  -  cinnamyl alcohol dehydrogenase 8

Arabidopsis thaliana

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Disease relevance of ELI3-2

  • We expressed a cDNA encoding the Arabidopsis thaliana defense-related protein ELI3-2 in Escherichia coli to determine its biochemical function [1].
  • ELI3 mRNA accumulates in A. thaliana leaves in response to challenge with phytopathogenic Pseudomonas syringae strains [2].

High impact information on ELI3-2

  • During incompatible interactions, where resistance in the plant genotype Col-0 is dictated by the dominant RPM1 locus, ELI3 mRNA accumulates to high levels 5-10 h post-inoculation [2].
  • Thus, the induction kinetics of ELI3 mRNA accumulation are consistent with a functional role for the ELI3 gene product in establishing the resistant phenotype [2].
  • Studies on the substrate specificity now revealed that ELI3-2 is an aromatic alcohol: NADP(+) oxidoreductase (benzyl alcohol dehydrogenase) [1].
  • Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3 [3].


  1. Arabidopsis thaliana defense-related protein ELI3 is an aromatic alcohol:NADP(+) oxidoreductase. Somssich, I.E., Wernert, P., Kiedrowski, S., Hahlbrock, K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Rapid activation of a novel plant defense gene is strictly dependent on the Arabidopsis RPM1 disease resistance locus. Kiedrowski, S., Kawalleck, P., Hahlbrock, K., Somssich, I.E., Dangl, J.L. EMBO J. (1992) [Pubmed]
  3. Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3. Williamson, J.D., Stoop, J.M., Massel, M.O., Conkling, M.A., Pharr, D.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
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