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Gene Review

NIT4  -  bifunctional nitrilase/nitrile hydratase NIT4

Arabidopsis thaliana

Synonyms: AtNIT4, NITRILASE 4, T6G21.6, nitrilase 4
 
 
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Disease relevance of NIT4

 

High impact information on NIT4

 

Associations of NIT4 with chemical compounds

  • NIT4 may play a role in cyanide detoxification during ethylene biosynthesis because extracts from senescent leaves of A. thaliana showed higher Ala(CN) hydratase/nitrilase activities than extracts from nonsenescent tissue [1].
 

Analytical, diagnostic and therapeutic context of NIT4

  • Full-length cDNA sequences for two NIT4 homologs from blue lupine were obtained by PCR using degenerate primers and RACE-experiments [3].

References

  1. The Arabidopsis thaliana isogene NIT4 and its orthologs in tobacco encode beta-cyano-L-alanine hydratase/nitrilase. Piotrowski, M., Schönfelder, S., Weiler, E.W. J. Biol. Chem. (2001) [Pubmed]
  2. The Nitrilase ZmNIT2 converts indole-3-acetonitrile to indole-3-acetic acid. Park, W.J., Kriechbaumer, V., Möller, A., Piotrowski, M., Meeley, R.B., Gierl, A., Glawischnig, E. Plant Physiol. (2003) [Pubmed]
  3. Cyanide metabolism in higher plants: cyanoalanine hydratase is a NIT4 homolog. Piotrowski, M., Volmer, J.J. Plant Mol. Biol. (2006) [Pubmed]
 
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