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Gene Review:

CBP20 - nuclear cap-binding protein subunit 20

Arabidopsis thaliana

Synonyms: ATCBP20, CAP-binding protein 20, MLN1.12, MLN1_12

Kmieciak, M. et al., Hugouvieux, V. et al., Papp, I. et al.

Papp, Mur, Dalmadi, Dulai, Koncz,

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Disease relevance of CBP20

Loss of the cbp20 function also confers hypersensitivity to abscisic acid during germination, significant reduction of stomatal conductance and greatly enhanced tolerance to drought [1].

High impact information on CBP20

Here, we show that the dimeric ABH1 and AtCBP20 subunits are ubiquitously expressed [2].
Expression of the wild type cDNA by CaMV35S promoter provides full genetic complementation of the pleiotropic cbp20 phenotype [1].
The AtCBP20 gene is located on chromosome V, and the AtCBP80 gene is encoded by chromosome II [3].
Among introns identified in the AtCBP20 gene, we discovered an U12 type intervening sequence (an AT-AC intron) [3].
In addition to the N-terminal part, which is similar to the human protein, AtCBP20 has a long C-terminus rich in arginine, glycine and aspartate residues [3].

Biological context of CBP20

Both proteins AtCBP20 and AtCBP80 are encoded by single-copy genes in the A. thaliana genome [3].

References

A mutation in the Cap Binding Protein 20 gene confers drought tolerance to Arabidopsis. Papp, I., Mur, L.A., Dalmadi, A., Dulai, S., Koncz, C. Plant Mol. Biol. (2004) [Pubmed]
Localization, ion channel regulation, and genetic interactions during abscisic acid signaling of the nuclear mRNA cap-binding protein, ABH1. Hugouvieux, V., Murata, Y., Young, J.J., Kwak, J.M., Mackesy, D.Z., Schroeder, J.I. Plant Physiol. (2002) [Pubmed]
Cloning and characterization of two subunits of Arabidopsis thaliana nuclear cap-binding complex. Kmieciak, M., Simpson, C.G., Lewandowska, D., Brown, J.W., Jarmolowski, A. Gene (2002) [Pubmed]

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