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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Bcl10  -  B-cell CLL/lymphoma 10

Rattus norvegicus

Synonyms: B-cell lymphoma/leukemia 10, Bcl-10, R-RCD1, RCD
 
 
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Disease relevance of Bcl10

  • Body weight gain was accelerated in rAAV-GFP + HFD control rats relative to those consuming RCD, despite equivalent kcal consumption [1].
 

High impact information on Bcl10

  • As a consequence of the latter, RCD is decreased and whole blood viscosity increased [2].
  • In addition, recruitment of TNFR-activating factor 2 was likely promoted by Bcl10-mediated sequestering of cellular inhibitor of apoptosis protein 2 [3].
  • Ingestion of diets adequate in vitamin D3 and containing either normal calcium (1.2% Ca, NC), reduced calcium (0.6% Ca, RCD) or low calcium (0.002% Ca, LCD) increased 1,25(OH)2D3 net synthesis (for male rats, NC vs. RCD vs. LCD 1.8 +/- 0.1 SEM vs. 9 +/- 2 vs. 17 +/- 2 pmol/mg protein/20 min; P less than 0.05 for all comparisons) [4].
 

Analytical, diagnostic and therapeutic context of Bcl10

  • Data have been published and are reviewed here in support of a possibility that APKD and RCD acquired during hemodialysis are premalignant lesions [5].

References

  1. Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels. Dube, M.G., Beretta, E., Dhillon, H., Ueno, N., Kalra, P.S., Kalra, S.P. Diabetes (2002) [Pubmed]
  2. Hypoalbuminemia causes high blood viscosity by increasing red cell lysophosphatidylcholine. Joles, J.A., Willekes-Koolschijn, N., Koomans, H.A. Kidney Int. (1997) [Pubmed]
  3. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda, S., Skradski, S.L., Araki, T., Schindler, C.K., Meller, R., Lan, J.Q., Taki, W., Simon, R.P., Henshall, D.C. Eur. J. Neurosci. (2003) [Pubmed]
  4. Effects of dietary calcium restriction on 1,25-dihydroxyvitamin D3 net synthesis by rat proximal tubules. Langman, C.B., Favus, M.J., Bushinsky, D.A., Coe, F.L. J. Lab. Clin. Med. (1985) [Pubmed]
  5. Cystic kidneys: an enigma evolves. Gardner, K.D., Evan, A.P. Am. J. Kidney Dis. (1984) [Pubmed]
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