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MeSH Review

Blood Viscosity

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Disease relevance of Blood Viscosity


High impact information on Blood Viscosity


Chemical compound and disease context of Blood Viscosity


Biological context of Blood Viscosity


Anatomical context of Blood Viscosity


Associations of Blood Viscosity with chemical compounds


Gene context of Blood Viscosity

  • A defibrinogenic agent, batroxobin, which may diminish shear stress by reduction of blood viscosity, prevented iNOS induction as well as early aneurysmal changes [30].
  • Among factors of blood viscosity, IGF-I exhibits a borderline correlation (p = 0.05) with "Tk" and the ratio IGF1/IGFBP3 which reflects free circulating IGF-I is correlated with red cell aggregability measured with the Myrenne "M" (r = 0.485, p = 0.014) and S60 (r = 0.396, p = 0.494) [31].
  • Von Willebrand factor (vWF), Factor VIII, plasma viscosity, haematocrit, blood viscosity, tissue plasminogen activator (t-PA) and fibrin D-dimer were measured at rest and following stressful tasks in 238 middle-aged British civil servants [32].
  • The risk of stroke was related to baseline levels of t-PA antigen (RR 1.87, 95% CI 1.04-3.34, P < or = 0.05) and whole blood viscosity (RR 1.33, 95% CI 1.07-1.65, P < or = 0.01) [33].
  • CONCLUSION: RF has apparent protective effects on hepatic injury by increasing activity of GSH-Px and SOD, scavenging free radicals produced by CCl(4), reducing blood viscosity, and improving microcirculation and blood supply [34].

Analytical, diagnostic and therapeutic context of Blood Viscosity


  1. Effect of low-dose subcutaneous heparin on whole-blood viscosity. Erdi, A., Thomas, D.P., Kakkar, V.V., Lane, D.A. Lancet (1976) [Pubmed]
  2. Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity. Vogel, J., Kiessling, I., Heinicke, K., Stallmach, T., Ossent, P., Vogel, O., Aulmann, M., Frietsch, T., Schmid-Schönbein, H., Kuschinsky, W., Gassmann, M. Blood (2003) [Pubmed]
  3. Increased cerebral infarct volumes in polyglobulic mice overexpressing erythropoietin. Wiessner, C., Allegrini, P.R., Ekatodramis, D., Jewell, U.R., Stallmach, T., Gassmann, M. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  4. Hypoalbuminemia causes high blood viscosity by increasing red cell lysophosphatidylcholine. Joles, J.A., Willekes-Koolschijn, N., Koomans, H.A. Kidney Int. (1997) [Pubmed]
  5. Hemorheological disturbances, metabolic parameters and blood pressure in different types of obesity. Wysocki, M., Krotkiewski, M., Braide, M., Bagge, U. Atherosclerosis (1991) [Pubmed]
  6. The vascular effects of L-Arginine in humans. The role of endogenous insulin. Giugliano, D., Marfella, R., Verrazzo, G., Acampora, R., Coppola, L., Cozzolino, D., D'Onofrio, F. J. Clin. Invest. (1997) [Pubmed]
  7. Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia. Jain, R.K., Shah, S.A., Finney, P.L. J. Natl. Cancer Inst. (1984) [Pubmed]
  8. Long-term cardiorespiratory effects of amelioration of renal anaemia by erythropoietin. Macdougall, I.C., Lewis, N.P., Saunders, M.J., Cochlin, D.L., Davies, M.E., Hutton, R.D., Fox, K.A., Coles, G.A., Williams, J.D. Lancet (1990) [Pubmed]
  9. Regulation of cerebral blood flow in response to changes in blood viscosity. Brown, M.M., Marshall, J. Lancet (1985) [Pubmed]
  10. Reduction in blood viscosity by eicosapentaenoic acid. Kobayashi, S., Hirai, A., Terano, T., Hamazaki, T., Tamura, Y., Kumagai, A. Lancet (1981) [Pubmed]
  11. Pentoxifylline efficacy in the treatment of intermittent claudication: multicenter controlled double-blind trial with objective assessment of chronic occlusive arterial disease patients. Porter, J.M., Cutler, B.S., Lee, B.Y., Reich, T., Reichle, F.A., Scogin, J.T., Strandness, D.E. Am. Heart J. (1982) [Pubmed]
  12. Regional hemodynamic responses to hypoxia in polycythemic dogs. Stork, R.L., Bredle, D.L., Chapler, C.K., Cain, S.M. J. Appl. Physiol. (1988) [Pubmed]
  13. Reduction of myocardial infarct size by poloxamer 188 and mannitol in a canine model. Justicz, A.G., Farnsworth, W.V., Soberman, M.S., Tuvlin, M.B., Bonner, G.D., Hunter, R.L., Martino-Saltzman, D., Sink, J.D., Austin, G.E. Am. Heart J. (1991) [Pubmed]
  14. Lovastatin alters blood rheology in primary hyperlipoproteinemia: dependence on lipoprotein(a)? Koenig, W., Hehr, R., Ditschuneit, H.H., Kuhn, K., Ernst, E., Rosenthal, J., Hombach, V. Journal of clinical pharmacology. (1992) [Pubmed]
  15. The mechanistic relationships between hemorheological characteristics and cardiovascular disease. Kensey, K.R. Current medical research and opinion. (2003) [Pubmed]
  16. Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants. Giugliano, D., Marfella, R., Verrazzo, G., Acampora, R., Donzella, C., Quatraro, A., Coppola, L., D'Onofrio, F. Ann. Intern. Med. (1995) [Pubmed]
  17. The effect of hematocrit and systolic blood pressure on cerebral blood flow in newborn infants. Younkin, D.P., Reivich, M., Jaggi, J.L., Obrist, W.D., Delivoria-Papadopoulos, M. J. Cereb. Blood Flow Metab. (1987) [Pubmed]
  18. Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia. Weissmann, N., Manz, D., Buchspies, D., Keller, S., Mehling, T., Voswinckel, R., Quanz, K., Ghofrani, H.A., Schermuly, R.T., Fink, L., Seeger, W., Gassmann, M., Grimminger, F. Thromb. Haemost. (2005) [Pubmed]
  19. Paradoxical hypotension following increased hematocrit and blood viscosity. Martini, J., Carpentier, B., Negrete, A.C., Frangos, J.A., Intaglietta, M. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  20. Depression of stimulated erythropoietin production in mice with enhanced erythropoiesis. Lezón, C., Alippi, R.M., Barceló, A.C., Martínez, M.P., Conti, M.I., Bozzini, C.E. Haematologica (1995) [Pubmed]
  21. Increased whole blood viscosity during coronary artery bypass surgery. Studies to evaluate the effects of soluble fibrin and poloxamer 188. Hunter, R.L., Papadea, C., Gallagher, C.J., Finlayson, D.C., Check, I.J. Thromb. Haemost. (1990) [Pubmed]
  22. Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects. Pope, C.A., Hansen, M.L., Long, R.W., Nielsen, K.R., Eatough, N.L., Wilson, W.E., Eatough, D.J. Environ. Health Perspect. (2004) [Pubmed]
  23. Effect of resveratrol on microcirculation disorder and lung injury following severe acute pancreatitis in rats. Meng, Y., Zhang, M., Xu, J., Liu, X.M., Ma, Q.Y. World J. Gastroenterol. (2005) [Pubmed]
  24. The differential effect of cooling on the responses of splenic capsular and vascular smooth muscle to nerve stimulation and noradrenaline. Davies, B.N., Powis, D.A., Withrington, P.G. Pflugers Arch. (1978) [Pubmed]
  25. Non-invasive evaluation of abdominal aortic properties: lumped circuit model and estimation of its parameters. Morishita, K., Kambe, M. Medical & biological engineering & computing. (1995) [Pubmed]
  26. Cocaine-induced erythrocytosis and increase in von Willebrand factor: evidence for drug-related blood doping and prothrombotic effects. Siegel, A.J., Sholar, M.B., Mendelson, J.H., Lukas, S.E., Kaufman, M.J., Renshaw, P.F., McDonald, J.C., Lewandrowski, K.B., Apple, F.S., Stec, J.J., Lipinska, I., Tofler, G.H., Ridker, P.M. Arch. Intern. Med. (1999) [Pubmed]
  27. Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide. Harenberg, J. Medicinal research reviews. (1998) [Pubmed]
  28. Lack of dependence of cerebral blood flow on blood viscosity after blood exchange with a Newtonian O2 carrier. Waschke, K.F., Krieter, H., Hagen, G., Albrecht, D.M., Van Ackern, K., Kuschinsky, W. J. Cereb. Blood Flow Metab. (1994) [Pubmed]
  29. Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis. Wannamethee, S.G., Lowe, G.D., Rumley, A., Bruckdorfer, K.R., Whincup, P.H. Am. J. Clin. Nutr. (2006) [Pubmed]
  30. Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase. Fukuda, S., Hashimoto, N., Naritomi, H., Nagata, I., Nozaki, K., Kondo, S., Kurino, M., Kikuchi, H. Circulation (2000) [Pubmed]
  31. Relationships between blood viscosity and insulin-like growth factor I status in athletes. Monnier, J.F., Benhaddad, A.A., Micallef, J.P., Mercier, J., Brun, J.F. Clin. Hemorheol. Microcirc. (2000) [Pubmed]
  32. Prolonged elevations in haemostatic and rheological responses following psychological stress in low socioeconomic status men and women. Steptoe, A., Kunz-Ebrecht, S., Rumley, A., Lowe, G.D. Thromb. Haemost. (2003) [Pubmed]
  33. Haemostatic factors and prediction of ischaemic heart disease and stroke in claudicants. Smith, F.B., Rumley, A., Lee, A.J., Leng, G.C., Fowkes, F.G., Lowe, G.D. Br. J. Haematol. (1998) [Pubmed]
  34. Protective effects of 5,4'-dihydroxy-3',5'-dimethoxy-7-O-beta-D -glucopyranosyloxy-flavone on experimental hepatic injury. Xu, D.H., Mei, X.T., Chen, Y., Li, Y.M., Lv, J.Y., Xu, S.B. World J. Gastroenterol. (2005) [Pubmed]
  35. Effects of defibrination on hemorheology, cerebral blood flow velocity, and CO2 reactivity during hypocapnia in normal subjects. Izumi, Y., Tsuda, Y., Ichihara, S., Takahashi, T., Matsuo, H. Stroke (1996) [Pubmed]
  36. Influence of cyclandelate on in vitro red blood cell deformability. Hall, D.W., van den Hoven, W.E. Drugs (1987) [Pubmed]
  37. Antiatherothrombotic effects of nicotinic acid. Rosenson, R.S. Atherosclerosis (2003) [Pubmed]
  38. Effect of oral administration of highly purified eicosapentaenoic acid on platelet function, blood viscosity and red cell deformability in healthy human subjects. Terano, T., Hirai, A., Hamazaki, T., Kobayashi, S., Fujita, T., Tamura, Y., Kumagai, A. Atherosclerosis (1983) [Pubmed]
  39. Effects of LDL apheresis on blood rheology in two patients with homozygous familial hypercholesterolaemia. Fadul, J.E., Sandhagen, B., Linde, T., Vessby, B., Wikström, B., Danielson, B.G. Blood Purif. (1997) [Pubmed]
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