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Gene Review

Bcl10  -  B cell leukemia/lymphoma 10

Mus musculus

Synonyms: AI132454, B-cell CLL/lymphoma 10, B-cell lymphoma/leukemia 10, BCL-10, Bcl-10, ...
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Disease relevance of Bcl10


High impact information on Bcl10

  • Thus, Bcl10 functions as a positive regulator of lymphocyte proliferation that specifically connects antigen receptor signaling in B and T cells to NF-kappaB activation [3].
  • Bcl10, a CARD-containing protein identified from the t(1;14)(p22;q32) breakpoint in MALT lymphomas, has been shown to induce apoptosis and activate NF-kappaB in vitro [3].
  • However, surviving bcl10-/- mice were severely immunodeficient and bcl10-/- lymphocytes are defective in antigen receptor or PMA/Ionomycin-induced activation [3].
  • Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types [2].
  • Truncated Bcl10 activated NF-kappaB but did not induce apoptosis [2].

Biological context of Bcl10

  • The defect in Rip2-/- T-cells correlated with a lack of TCR-induced Bcl10 phosphorylation [4].
  • Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein [5].
  • NKT cells, on the other hand, require PKCtheta for thymic development, whereas absence of Bcl10 leads primarily to the reduction of peripheral NKT cell numbers [6].
  • Bcl10 downregulation is not affected by proteasome inhibitors but is accompanied by transient localization to lysosomal vesicles, suggesting involvement of the lysosomal pathway rather than the proteasome [7].
  • Through activation of NF-kappaB, v-CARMEN may regulate the expression of the cellular and viral genes important for viral replication [8].

Anatomical context of Bcl10

  • In contrast to Bcl10 disruption, however, inactivation of Malt1 has only mild effects on B cell activation and does not cause defects during neurodevelopment [9].
  • Bcl10 is an intracellular protein essential for nuclear factor (NF)-kappaB activation after lymphocyte antigen receptor stimulation [10].
  • These findings also uncover a function of the CARMA, Bcl10, and MALT1 proteins in cells outside the immune system [11].
  • TCR activation causes enrichment of PKC at the c-SMAC, followed by Bcl10 relocalization to punctate cytoplasmic structures, often at sites distant from the c-SMAC [12].
  • Synchronized HCT116 3-6 cells treated with a low dose of FdUrd had a 2-fold greater G(2) cell cycle arrest compared with MMR-deficient HCT116 cells, and asynchronous ME-10 cells demonstrated a 4-fold greater G(2) arrest after FdUrd treatment compared with CT-5 cells [13].

Associations of Bcl10 with chemical compounds


Physical interactions of Bcl10

  • Although the paracaspase MALT1 can bind to BCL10, the physiological function of MALT1 is unknown [9].
  • The recruitment of BCL10 to TLR4 signaling complexes was attenuated by induced expression of SOCS3 in a feedback loop [16].

Other interactions of Bcl10


Analytical, diagnostic and therapeutic context of Bcl10


  1. The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. Klemm, S., Gutermuth, J., Hültner, L., Sparwasser, T., Behrendt, H., Peschel, C., Mak, T.W., Jakob, T., Ruland, J. J. Exp. Med. (2006) [Pubmed]
  2. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Willis, T.G., Jadayel, D.M., Du, M.Q., Peng, H., Perry, A.R., Abdul-Rauf, M., Price, H., Karran, L., Majekodunmi, O., Wlodarska, I., Pan, L., Crook, T., Hamoudi, R., Isaacson, P.G., Dyer, M.J. Cell (1999) [Pubmed]
  3. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Ruland, J., Duncan, G.S., Elia, A., del Barco Barrantes, I., Nguyen, L., Plyte, S., Millar, D.G., Bouchard, D., Wakeham, A., Ohashi, P.S., Mak, T.W. Cell (2001) [Pubmed]
  4. Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation. Ruefli-Brasse, A.A., Lee, W.P., Hurst, S., Dixit, V.M. J. Biol. Chem. (2004) [Pubmed]
  5. Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein. Yoneda, T., Imaizumi, K., Maeda, M., Yui, D., Manabe, T., Katayama, T., Sato, N., Gomi, F., Morihara, T., Mori, Y., Miyoshi, K., Hitomi, J., Ugawa, S., Yamada, S., Okabe, M., Tohyama, M. J. Biol. Chem. (2000) [Pubmed]
  6. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Schmidt-Supprian, M., Tian, J., Grant, E.P., Pasparakis, M., Maehr, R., Ovaa, H., Ploegh, H.L., Coyle, A.J., Rajewsky, K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Scharschmidt, E., Wegener, E., Heissmeyer, V., Rao, A., Krappmann, D. Mol. Cell. Biol. (2004) [Pubmed]
  8. Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase. Thome, M., Martinon, F., Hofmann, K., Rubio, V., Steiner, V., Schneider, P., Mattmann, C., Tschopp, J. J. Biol. Chem. (1999) [Pubmed]
  9. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Ruland, J., Duncan, G.S., Wakeham, A., Mak, T.W. Immunity (2003) [Pubmed]
  10. Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Xue, L., Morris, S.W., Orihuela, C., Tuomanen, E., Cui, X., Wen, R., Wang, D. Nat. Immunol. (2003) [Pubmed]
  11. CARMA3/Bcl10/MALT1-dependent NF-{kappa}B activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. McAllister-Lucas, L.M., Ruland, J., Siu, K., Jin, X., Gu, S., Kim, D.S., Kuffa, P., Kohrt, D., Mak, T.W., Nu??ez, G., Lucas, P.C. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  12. Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. Schaefer, B.C., Kappler, J.W., Kupfer, A., Marrack, P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  13. Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. Meyers, M., Wagner, M.W., Hwang, H.S., Kinsella, T.J., Boothman, D.A. Cancer Res. (2001) [Pubmed]
  14. Bcl10 and Malt1 control lysophosphatidic acid-induced NF-{kappa}B activation and cytokine production. Klemm, S., Zimmermann, S., Peschel, C., Mak, T.W., Ruland, J. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  15. B Cell Lymphoma 10 Is Essential for Fc{epsilon}R-Mediated Degranulation and IL-6 Production in Mast Cells. Chen, Y., Pappu, B.P., Zeng, H., Xue, L., Morris, S.W., Lin, X., Wen, R., Wang, D. J. Immunol. (2007) [Pubmed]
  16. BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. Liu, Y., Dong, W., Chen, L., Xiang, R., Xiao, H., De, G., Wang, Z., Qi, Y. J. Biol. Chem. (2004) [Pubmed]
  17. Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Egawa, T., Albrecht, B., Favier, B., Sunshine, M.J., Mirchandani, K., O'Brien, W., Thome, M., Littman, D.R. Curr. Biol. (2003) [Pubmed]
  18. Bcl10/Malt1 Signaling Is Essential for TCR-Induced NF-{kappa}B Activation in Thymocytes but Dispensable for Positive or Negative Selection. Jost, P.J., Weiss, S., Ferch, U., Gross, O., Mak, T.W., Peschel, C., Ruland, J. J. Immunol. (2007) [Pubmed]
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