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Gene Review

Tnfrsf1a  -  tumor necrosis factor receptor superfamily...

Rattus norvegicus

Synonyms: TNF-R1, TNF-RI, TNFR-1, TNFR-I, Tnfr-1, ...
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Disease relevance of Tnfrsf1a


High impact information on Tnfrsf1a


Chemical compound and disease context of Tnfrsf1a


Biological context of Tnfrsf1a


Anatomical context of Tnfrsf1a


Associations of Tnfrsf1a with chemical compounds

  • Methylprednisolone (MP), a synthetic glucocorticoid, partially inhibited the injury-induced expression of TNFR1 and TNFR2, an effect which could be reversed by RU486, an antagonist of glucocorticoid receptors [14].
  • A single injection of recombinant TNF receptor P75 (etanercept) was given subcutaneously 24 hours before the administration of LPS [17].
  • In addition, the intracellular signaling intermediate from the TNFR1 receptor, ceramide, caused a similar increase in CGRP release [18].
  • Protection against liver injury by PGE1 or anti-TNF-alpha is associated with a reduction of TNF-R1 expression in hepatocytes [19].
  • Similar results were also obtained between pulmonary TNF-alpha mRNA expression and myeloperoxidase activities (P<0.01), whereas there was a highly negative correlation between levels of renal TNFR-I mRNA expression and serum creatinine [20].

Physical interactions of Tnfrsf1a


Co-localisations of Tnfrsf1a

  • TNF receptors TNFRI and TNFRII co-localized with biotinylated TNF-alpha tracer along the nerve trunk, suggesting that TNF-alpha transport may be receptor-mediated [22].
  • In thymocytes, AQP-1 is present and was shown to colocalize with the plasma membrane receptor tumor necrosis factor receptor-1 (TNF-R1) both before and after the AVD, which suggests that this protein is not proteolytically cleaved and remains on the cell membrane [23].

Regulatory relationships of Tnfrsf1a

  • In this study we show that the retinal autoantigen, S-antigen, contains a functional TNF-alpha homologous domain which stimulates maturation and differentiation of cultured dendritic cells (DC) or tissue DC via the p55 TNF-alpha receptor [24].

Other interactions of Tnfrsf1a

  • The temporal pattern of TNFR2 expression was similar to that of TNFR1 but its expression peaked at 4 h postinjury [14].
  • Subsequently, protein phosphatase 5 translocated into the nuclei of degenerating CA3 neurons, while ASK1 colocalized with the adaptor proteins Daxx and TNFR-activating factor 2 at the outer membrane of injured CA3 neurons [13].
  • In the present work, we have assessed the effects on glomerular injury of blocking and binding of IL-1 to its receptor by rh IL-1 receptor antagonist (IL-1ra) and by neutralizing IL-1 and TNF with rm soluble IL-1 receptor type1 (sIL-1Rt1) and rh sTNF receptor (sTNFr p55), respectively [25].
  • Isolated ECL cells were found to express the TNF receptor p55 and IFN-gamma receptor, but not the TNF receptor p75 or CD95 [26].
  • Modulation of antibody-mediated glomerular injury in vivo by IL-1ra, soluble IL-1 receptor, and soluble TNF receptor [25].

Analytical, diagnostic and therapeutic context of Tnfrsf1a


  1. Experimental intestinal endometriosis is characterized by increased levels of soluble TNFRSF1B and downregulation of Tnfrsf1a and Tnfrsf1b gene expression. Rojas-Cartagena, C., Appleyard, C.B., Santiago, O.I., Flores, I. Biol. Reprod. (2005) [Pubmed]
  2. Effect of low-protein diet and protein supplementation on the expressions of TNF-alpha, TNFR-I, and TNFR-II in organs and muscle of LPS-injected rats. Raina, N., Jeejeebhoy, K.N. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  3. Immunocytochemical localization of TNF type 1 and type 2 receptors in the rat spinal cord. Holmes, G.M., Hebert, S.L., Rogers, R.C., Hermann, G.E. Brain Res. (2004) [Pubmed]
  4. Pentoxyphilline as a cyclooxygenase (cox-2) inhibitor in experimental sepsis. Modzelewski, B., Janiak, A. Med. Sci. Monit. (2004) [Pubmed]
  5. Selective up-regulation of tumor necrosis factor receptor I in tumor-bearing rats with cancer-related cachexia. Catalano, M.G., Fortunati, N., Arena, K., Costelli, P., Aragno, M., Danni, O., Boccuzzi, G. Int. J. Oncol. (2003) [Pubmed]
  6. Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins. Yang, Z., Makita, Z., Horii, Y., Brunelle, S., Cerami, A., Sehajpal, P., Suthanthiran, M., Vlassara, H. J. Exp. Med. (1991) [Pubmed]
  7. A novel signaling mechanism between gas and blood compartments of the lung. Kuebler, W.M., Parthasarathi, K., Wang, P.M., Bhattacharya, J. J. Clin. Invest. (2000) [Pubmed]
  8. Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk. Folli, F., Kahn, C.R., Hansen, H., Bouchie, J.L., Feener, E.P. J. Clin. Invest. (1997) [Pubmed]
  9. A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Cunha, T.M., Verri, W.A., Silva, J.S., Poole, S., Cunha, F.Q., Ferreira, S.H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells. Rodriguez, D.A., Moncada, C., Núñez, M.T., Lavandero, S., Ponnappa, B.C., Israel, Y. Alcohol (2004) [Pubmed]
  11. Corynebacterium parvum- and Mycobacterium bovis bacillus Calmette-Guerin-induced granuloma formation is inhibited in TNF receptor I (TNF-RI) knockout mice and by treatment with soluble TNF-RI. Senaldi, G., Yin, S., Shaklee, C.L., Piguet, P.F., Mak, T.W., Ulich, T.R. J. Immunol. (1996) [Pubmed]
  12. Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells. Ogawa, W., Hosomi, Y., Roth, R.A. Endocrinology (1995) [Pubmed]
  13. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda, S., Skradski, S.L., Araki, T., Schindler, C.K., Meller, R., Lan, J.Q., Taki, W., Simon, R.P., Henshall, D.C. Eur. J. Neurosci. (2003) [Pubmed]
  14. Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats. Yan, P., Liu, N., Kim, G.M., Xu, J., Xu, J., Li, Q., Hsu, C.Y., Xu, X.M. Exp. Neurol. (2003) [Pubmed]
  15. Adenoviral vectors encoding tumor necrosis factor-alpha and FasL induce apoptosis of normal and tumoral anterior pituitary cells. Candolfi, M., Jaita, G., Pisera, D., Ferrari, L., Barcia, C., Liu, C., Yu, J., Liu, G., Castro, M.G., Seilicovich, A. J. Endocrinol. (2006) [Pubmed]
  16. Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat. Schäfers, M., Sorkin, L.S., Geis, C., Shubayev, V.I. Neurosci. Lett. (2003) [Pubmed]
  17. Contribution of TNF-alpha to leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis in vivo. Koizumi, K., Poulaki, V., Doehmen, S., Welsandt, G., Radetzky, S., Lappas, A., Kociok, N., Kirchhof, B., Joussen, A.M. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  18. Tumor necrosis factor-alpha stimulation of calcitonin gene-related peptide expression and secretion from rat trigeminal ganglion neurons. Bowen, E.J., Schmidt, T.W., Firm, C.S., Russo, A.F., Durham, P.L. J. Neurochem. (2006) [Pubmed]
  19. Protection against liver injury by PGE1 or anti-TNF-alpha is associated with a reduction of TNF-R1 expression in hepatocytes. Lozano, J.M., Collado, J.A., Medina, T., Muntané, J. Scand. J. Gastroenterol. (2003) [Pubmed]
  20. The mRNA expression patterns of tumor necrosis factor-alpha and TNFR-I in some vital organs after thermal injury. Fang, W.H., Yao, Y.M., Shi, Z.G., Yu, Y., Wu, Y., Lu, L.R., Sheng, Z.Y. World J. Gastroenterol. (2003) [Pubmed]
  21. Synergistic stimulation of MHC class I and IRF-1 gene expression by IFN-gamma and TNF-alpha in oligodendrocytes. Agresti, C., Bernardo, A., Del Russo, N., Marziali, G., Battistini, A., Aloisi, F., Levi, G., Coccia, E.M. Eur. J. Neurosci. (1998) [Pubmed]
  22. Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. Shubayev, V.I., Myers, R.R. J. Neuroimmunol. (2001) [Pubmed]
  23. Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease. Jablonski, E.M., Webb, A.N., McConnell, N.A., Riley, M.C., Hughes, F.M. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  24. Induction or suppression of a B cell-specific response to self antigen in vivo is dependent upon dendritic cell activation via the TNF-alpha receptor at the time of antigen uptake. Liversidge, J., Dick, A., Daniels, G., Dawson, R. Eur. J. Immunol. (2000) [Pubmed]
  25. Modulation of antibody-mediated glomerular injury in vivo by IL-1ra, soluble IL-1 receptor, and soluble TNF receptor. Karkar, A.M., Tam, F.W., Steinkasserer, A., Kurrle, R., Langner, K., Scallon, B.J., Meager, A., Rees, A.J. Kidney Int. (1995) [Pubmed]
  26. Tumor necrosis factor-alpha effects on rat gastric enterochromaffin-like cells. Huber, C., Zanner, R., Pohlinger, A., Mahr, S., Neu, B., Prinz, C. Digestion (2002) [Pubmed]
  27. Shedding of tumor necrosis factor type 1 receptor after experimental spinal cord injury. Harrington, J.F., Messier, A.A., Levine, A., Szmydynger-Chodobska, J., Chodobski, A. J. Neurotrauma (2005) [Pubmed]
  28. Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: role of TNF-alpha. Nagakawa, Y., Williams, G.M., Zheng, Q., Tsuchida, A., Aoki, T., Montgomery, R.A., Klein, A.S., Sun, Z. Hepatology (2005) [Pubmed]
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