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Gene Review:

SPDS3 - Spermine synthase

Arabidopsis thaliana

Synonyms: ATSPDS3, MFH8.5, MFH8_5, SPERMIDINE SYNTHASE 3, SPMS, ...

Kitashiba, H. et al., Imai, A. et al., Hanzawa, Y. et al., Panicot, M. et al.

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High impact information on SPDS3

The SPDS and SPMS proteins showed no homodimerization but formed heterodimers in vitro [1].
However, SPMS was able to complement the speDelta4 spermine deficiency in yeast, indicating that SPMS is a novel spermine synthase [1].
Three cDNAs with high homology to spermine (Spm) synthases in Arabidopsis were isolated from apple [Malus sylvestris (L.) Mill. var. domestica (Borkh.) Mansf.]. MdACL5-1 and MdACL5-2 have high homology with ACL5 and MdSPMS has high homology with AtSPMS [2].
The genome of Arabidopsis thaliana has two genes encoding spermine synthase: ACAULIS5 (ACL5), whose loss-of-function mutants show a severe defect in stem elongation, and SPMS [3].

Other interactions of SPDS3

Here we report the characterization of the other three genes, designated SPDS1, SPDS2 and SPDS3 [4].

References

A polyamine metabolon involving aminopropyl transferase complexes in Arabidopsis. Panicot, M., Minguet, E.G., Ferrando, A., Alcázar, R., Blázquez, M.A., Carbonell, J., Altabella, T., Koncz, C., Tiburcio, A.F. Plant Cell (2002) [Pubmed]
Two types of spermine synthase gene: MdACL5 and MdSPMS are differentially involved in apple fruit development and cell growth. Kitashiba, H., Hao, Y.J., Honda, C., Moriguchi, T. Gene (2005) [Pubmed]
Spermine is not essential for survival of Arabidopsis. Imai, A., Akiyama, T., Kato, T., Sato, S., Tabata, S., Yamamoto, K.T., Takahashi, T. FEBS Lett. (2004) [Pubmed]
Characterization of the spermidine synthase-related gene family in Arabidopsis thaliana. Hanzawa, Y., Imai, A., Michael, A.J., Komeda, Y., Takahashi, T. FEBS Lett. (2002) [Pubmed]

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