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Gene Review

HIST1H4F  -  histone cluster 1, H4f

Homo sapiens

Synonyms: H4, H4/c, H4FC
 
 
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High impact information on HIST1H4F

  • Similar results were found in HeLa S3 and HL60 cells for the cell cycle-dependent human H4 histone gene FO108 [1].
  • The proliferation-specific transcription factor complex HiNF-D interacts with sequence specificity in a proximal promoter element of the human H4 histone gene FO108, designated Site II [2].
  • Downregulation of transcription from the H4 gene occurs concomitant with the loss of the HiNF-D/Site II interaction, further suggesting a functional relationship between Site II occupancy and the capacity for transcription [2].
  • To test for regulatory elements within the coding region, we performed transient transfection experiments in HeLa cells using constructs with histone H4 sequences fused upstream of a heterologous thymidine kinase promoter and CAT reporter gene [3].
  • Our results indicate that the proximal 200 nucleotides of the histone H4-coding region contain transcriptional regulatory elements that may contribute to cell-cycle control of histone gene expression by interacting with repressor complexes containing CDP/cut homeodomain transcription factors [3].
 

Biological context of HIST1H4F

  • The coding region of the human histone H4 gene FO108 undergoes dynamic changes in chromatin structure that correlate with modifications in gene expression [3].
  • Upon analysis of the regulatory elements of the FO108 histone H4 gene, we identified several potential YY1 binding sites [4].

References

  1. The human H1 histone gene FNC16 is functionally expressed in proliferating HeLa S3 cells and is down-regulated during terminal differentiation in HL60 cells. Collar, D.G., Wright, K.L., van Wijnen, A.J., Ramsey, A.L., Lian, J., Stein, J.L., Stein, G.S. J. Biol. Chem. (1988) [Pubmed]
  2. Multiple mechanisms regulate the proliferation-specific histone gene transcription factor HiNF-D in normal human diploid fibroblasts. Wright, K.L., Dell'Orco, R.T., van Wijnen, A.J., Stein, J.L., Stein, G.S. Biochemistry (1992) [Pubmed]
  3. Repressor elements in the coding region of the human histone H4 gene interact with the transcription factor CDP/cut. Last, T.J., Birnbaum, M., van Wijnen, A.J., Stein, G.S., Stein, J.L. Gene (1998) [Pubmed]
  4. Multiple interactions of the transcription factor YY1 with human histone H4 gene regulatory elements. Last, T.J., van Wijnen, A.J., Birnbaum, M.J., Stein, G.S., Stein, J.L. J. Cell. Biochem. (1999) [Pubmed]
 
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