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Gene Review: 

Pias3  -  protein inhibitor of activated STAT, 3

Rattus norvegicus

Synonyms: E3 SUMO-protein ligase PIAS3, KChAP, Potassium channel-associated protein, Protein inhibitor of activated STAT protein 3
 
 
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High impact information on Pias3

  • Here we report the cloning of a novel gene encoding a Kv channel binding protein (KChAP, for K+ channel-associated protein), which modulates the expression of Kv2 channels in heterologous expression system assays [1].
  • Kv2.1 and KChAP were coimmunoprecipitated from in vitro translation reactions supporting a direct interaction between the two proteins [1].
  • Although KChAP binds to Kv1.5, it has no effect on Kv1.5 currents [1].
  • 1 and Kv2.2 currents are enhanced dramatically in Xenopus oocytes coexpressing KChAP, but channel kinetics and gating are unaffected [1].
  • Although KChAP belongs to a family of proteins that interact with transcription factors, upregulation of channel currents was not blocked by the transcription inhibitor actinomycin D [2].

References

  1. Cloning and expression of a novel K+ channel regulatory protein, KChAP. Wible, B.A., Yang, Q., Kuryshev, Y.A., Accili, E.A., Brown, A.M. J. Biol. Chem. (1998) [Pubmed]
  2. KChAP as a chaperone for specific K(+) channels. Kuryshev, Y.A., Gudz, T.I., Brown, A.M., Wible, B.A. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
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