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Gene Review

Kcna6  -  potassium channel, voltage gated shaker...

Rattus norvegicus

Synonyms: Potassium voltage-gated channel subfamily A member 6, RCK2, Voltage-gated potassium channel subunit Kv1.6, Voltage-gated potassium channel subunit Kv2
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Disease relevance of Kcna6

  • This suggests that impaired Kv2 channel activity may contribute to arterial dysfunction during hypertension [1].
  • A chimeric protein containing the hemagglutinin protein from influenza virus and the region of Kv2.1 that differentiates the two truncation mutants (amino acids 536-666) was also expressed in MDCK cells, where it was found in high density clusters similar to those observed for Kv2 [2].
  • In cultured rat hippocampal neurons, chemical ischemia (CI) elicited a similar dephosphorylation and translocation of Kv2 [3].

High impact information on Kcna6

  • The Kv2 mRNA is expressed only in brain, whereas the Kv1 and Kv3 transcripts are found in several other tissues as well [4].
  • RCK2 mRNA was detected predominantly in midbrain areas and brainstem [5].
  • Here we report the cloning of a novel gene encoding a Kv channel binding protein (KChAP, for K+ channel-associated protein), which modulates the expression of Kv2 channels in heterologous expression system assays [6].
  • This study establishes that Kv2 and 1 channel homologs mediate the majority of repolarizing delayed rectifier current in rat beta-cells and that antagonism of Kv2.1 may prove to be a novel glucose-dependent therapeutic treatment for type 2 diabetes [7].
  • Phosphoamino acid analysis of Kv2.1 expressed in transfected cells and labeled in vivo with 32P shows that phosphorylation was restricted to serine residues and that a truncation mutant, DeltaC318, which lacks the last 318 amino acids in the cytoplasmic carboxyl terminus, was phosphorylated to a much lesser degree than was wild-type Kv2 [8].

Chemical compound and disease context of Kcna6


Biological context of Kcna6

  • In addition, our analysis indicates that a substantial component (approximately 50%) of the voltage dependencies and kinetics of Kv currents in voltage-clamped cerebral arterial myocytes is consistent with Kv2 channels [1].
  • The deduced amino acid sequence is 816 residues, and shares a 56-59% sequence identity with Kv2.1 and Kv2.2, the other members of the vertebrate Kv2 subfamily of voltage-gated K(+) channels [9].
  • Neither of the two protocols affected gene expression of the ion channel-associated proteins Kir6.2, sulfonylurea receptor 1, voltage-dependent calcium channel-alpha1, or Kv2 [10].
  • Finally, Chinese hamster ovary cells, which do not express endogenous voltage-gated K+ channels, became substantially more sensitive to apoptosis after transient expression of wild-type Kv2 [11].

Anatomical context of Kcna6

  • A novel member of the RCK family of rat brain K+ channels, called RCK2, has been sequenced and expressed in Xenopus oocytes [12].
  • In this study, we tested the hypothesis Kv2 channels may also significantly regulate tone of rat cerebral arteries [1].
  • On the basis of these novel observations, we propose a new model of Kv channel function in arterial smooth muscle in which Kv2 channels (in combination with Kv1 channels) contribute to membrane hyperpolarization and thus oppose constriction [1].
  • Taken together, results provide evidence for the expression of Kv2 sequences in the X. laevis inner ear and brain [13].

Associations of Kcna6 with chemical compounds

  • We report here that the cytoplasmic NH2-terminal domains of Kv1, Kv2, Kv3, and Kv4 subfamilies each associate to form homomultimers [14].
  • Adenovirus-mediated expression of a C-terminal truncated Kv2.1 subunit, specifically eliminating Kv2 family currents, reduced delayed rectifier currents in these cells by 60-70% and enhanced glucose-stimulated insulin secretion from rat islets by 60% [7].

Analytical, diagnostic and therapeutic context of Kcna6


  1. Kv2 channels oppose myogenic constriction of rat cerebral arteries. Amberg, G.C., Santana, L.F. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  2. Identification of a cytoplasmic domain important in the polarized expression and clustering of the Kv2.1 K+ channel. Scannevin, R.H., Murakoshi, H., Rhodes, K.J., Trimmer, J.S. J. Cell Biol. (1996) [Pubmed]
  3. Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia. Misonou, H., Mohapatra, D.P., Menegola, M., Trimmer, J.S. J. Neurosci. (2005) [Pubmed]
  4. Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain. Swanson, R., Marshall, J., Smith, J.S., Williams, J.B., Boyle, M.B., Folander, K., Luneau, C.J., Antanavage, J., Oliva, C., Buhrow, S.A. Neuron (1990) [Pubmed]
  5. Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. Grupe, A., Schröter, K.H., Ruppersberg, J.P., Stocker, M., Drewes, T., Beckh, S., Pongs, O. EMBO J. (1990) [Pubmed]
  6. Cloning and expression of a novel K+ channel regulatory protein, KChAP. Wible, B.A., Yang, Q., Kuryshev, Y.A., Accili, E.A., Brown, A.M. J. Biol. Chem. (1998) [Pubmed]
  7. Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion. MacDonald, P.E., Ha, X.F., Wang, J., Smukler, S.R., Sun, A.M., Gaisano, H.Y., Salapatek, A.M., Backx, P.H., Wheeler, M.B. Mol. Endocrinol. (2001) [Pubmed]
  8. Phosphorylation of the Kv2.1 K+ channel alters voltage-dependent activation. Murakoshi, H., Shi, G., Scannevin, R.H., Trimmer, J.S. Mol. Pharmacol. (1997) [Pubmed]
  9. Molecular cloning and functional characterization of a novel delayed rectifier potassium channel from channel catfish (Ictalurus punctatus): expression in taste buds. Kang, J., Teeter, J.H., Brazier, S.P., Nguyen, N.D., Chang, C.C., Puchalski, R.B. J. Neurochem. (2001) [Pubmed]
  10. Short-term intermittent exposure to diazoxide improves functional performance of beta-cells in a high-glucose environment. Yoshikawa, H., Ma, Z., Björklund, A., Grill, V. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  11. Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels. Pal, S., Hartnett, K.A., Nerbonne, J.M., Levitan, E.S., Aizenman, E. J. Neurosci. (2003) [Pubmed]
  12. Electrophysiological characterization of a new member of the RCK family of rat brain K+ channels. Kirsch, G.E., Drewe, J.A., Verma, S., Brown, A.M., Joho, R.H. FEBS Lett. (1991) [Pubmed]
  13. Detection of transcripts for delayed rectifier potassium channels in the Xenopus laevis inner ear. Varela-Ramírez, A., Trujillo-Provencio, C., Serrano, E.E. Hear. Res. (1998) [Pubmed]
  14. Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits. Xu, J., Yu, W., Jan, Y.N., Jan, L.Y., Li, M. J. Biol. Chem. (1995) [Pubmed]
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