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Gene Review:

MOM - helicase protein MOM1

Arabidopsis thaliana

Synonyms: MAINTENANCE OF METHYLATION, MOM1, MORPHEUS MOLECULE, MORPHEUS MOLECULE 1, T6D22.14, ...

Mittelsten Scheid, O. et al., Amedeo, P. et al., Liu, T.L. et al., Vaillant, I. et al.

Mittelsten Scheid, Probst, Afsar, Paszkowski,

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High impact information on MOM

We have isolated an Arabidopsis gene, MOM, whose product is required for the maintenance of transcriptional gene silencing [1].
MOM is the first known molecular component that is essential for transcriptional gene silencing and does not affect methylation pattern [1].
Disruption of the plant gene MOM releases transcriptional silencing of methylated genes [1].
The synergistic release of TGS revealed by gene expression patterns from silent loci, drastic developmental abnormalities, and characteristic changes in nuclear architecture in these double mutants implies that DDM1 and MOM are likely to operate at independent levels in TGS control [2].
Two mutants described earlier, ddm1 and mom1, reactivate previously silent loci: ddm1 impairs TGS by reducing chromosomal DNA methylation, and mom1 releases TGS without affecting DNA methylation [2].

Biological context of MOM

In sequence-based map of Arabidopsis genes with Mutant phenotype (SMAGMP) mutant ses was between ATlg06150 (EMB1444) and ATlg08060 (MOM) [3].
MOM1 mediates DNA-methylation-independent silencing of repetitive sequences in Arabidopsis [4].

References

Disruption of the plant gene MOM releases transcriptional silencing of methylated genes. Amedeo, P., Habu, Y., Afsar, K., Mittelsten Scheid, O., Paszkowski, J. Nature (2000) [Pubmed]
Two regulatory levels of transcriptional gene silencing in Arabidopsis. Mittelsten Scheid, O., Probst, A.V., Afsar, K., Paszkowski, J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
How to map ses, a mutant of Arabidopsis thaliana affecting pollen development. Liu, T.L., Kuai, B.K., Liu, Z.X., Zhao, D.L., Shen, D.L. Genetika (2006) [Pubmed]
MOM1 mediates DNA-methylation-independent silencing of repetitive sequences in Arabidopsis. Vaillant, I., Schubert, I., Tourmente, S., Mathieu, O. EMBO Rep. (2006) [Pubmed]

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