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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KU70  -  ATP-dependent DNA helicase 2 subunit KU70

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA KU70 HOMOLOG, ATKU70, F6I1.2, F6I1_2, KU70 homolog, ...
 
 
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Disease relevance of ATKU70/KU70

 

High impact information on ATKU70/KU70

  • We report the molecular characterization of the KU70 and KU80 genes in Arabidopsis and describe the consequences of a Ku70 deficiency [2].
  • The KU70 gene also plays a role in maintaining telomere length [1].
  • In other organisms the KU70 gene has been shown to play a role in the repair of DNA damage induced by ionising radiation (IR) and by radiomimetic chemicals such as methylmethane sulfonate (MMS) [1].

References

  1. Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant. Bundock, P., van Attikum, H., Hooykaas, P. Nucleic Acids Res. (2002) [Pubmed]
  2. Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70. Riha, K., Watson, J.M., Parkey, J., Shippen, D.E. EMBO J. (2002) [Pubmed]
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