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Gene Review

XRCC6  -  X-ray repair complementing defective...

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High impact information on XRCC6

  • To investigate the distinctive as well as redundant roles of these two repair pathways, we analyzed the mutants RAD54(-/-), KU70(-/-) and RAD54(-/-)/KU70(-/-), generated from the chicken B-cell line DT40 [1].
  • 53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis [2].

Biological context of XRCC6

  • Genetic analyses confirm this suggestion as we have demonstrated an epistatic relationship between 53BP1 and the NHEJ genes, Ku70 and Artemis, but not with Rad54, a gene essential for repair of DSBs by homologous recombination [3].


  1. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. Takata, M., Sasaki, M.S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi-Iwai, Y., Shinohara, A., Takeda, S. EMBO J. (1998) [Pubmed]
  2. 53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis. Iwabuchi, K., Hashimoto, M., Matsui, T., Kurihara, T., Shimizu, H., Adachi, N., Ishiai, M., Yamamoto, K., Tauchi, H., Takata, M., Koyama, H., Date, T. Genes Cells (2006) [Pubmed]
  3. Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks. Nakamura, K., Sakai, W., Kawamoto, T., Bree, R.T., Lowndes, N.F., Takeda, S., Taniguchi, Y. DNA Repair (Amst.) (2006) [Pubmed]
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