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Gene Review:

KU80 - ATP-dependent DNA helicase 2 subunit KU80

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA KU80 HOMOLOG, ATKU80, KU80-LIKE PROTEIN, T2J15.4

Li, J. et al., West, C.E. et al., Riha, K. et al., West, C.E. et al.

West, Waterworth, Sunderland, Bray,

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Disease relevance of ATKU80/KU80

We show that ku80-mutant Arabidopsis plants are defective in T-DNA integration in somatic cells, whereas KU80-overexpressing plants exhibit increased susceptibility to Agrobacterium infection and increased resistance to DNA-damaging agents [1].
An atku80 knockout mutant shows hypersensitivity to the DNA-damaging agents menadione and bleomycin, consistent with a role for AtKu80 in the repair of DSBs in vivo in Arabidopsis [2].

High impact information on ATKU80/KU80

We report the molecular characterization of the KU70 and KU80 genes in Arabidopsis and describe the consequences of a Ku70 deficiency [3].
Previously, the Arabidopsis NHEJ mutant atku80 was isolated and found to display hypersensitivity to bleomycin, a drug that causes DSBs in DNA [4].

Associations of ATKU80/KU80 with chemical compounds

In the present study, the transcript profiles of wild-type and atku80 mutant plants grown in the presence and absence of bleomycin are determined by microarray analysis [4].

Analytical, diagnostic and therapeutic context of ATKU80/KU80

The direct interaction between dsT-DNA molecules and KU80 in planta was confirmed by immunoprecipitation of KU80 dsT-DNA complexes from Agrobacterium-infected plants [1].

References

Involvement of KU80 in T-DNA integration in plant cells. Li, J., Vaidya, M., White, C., Vainstein, A., Citovsky, V., Tzfira, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Disruption of the Arabidopsis AtKu80 gene demonstrates an essential role for AtKu80 protein in efficient repair of DNA double-strand breaks in vivo. West, C.E., Waterworth, W.M., Story, G.W., Sunderland, P.A., Jiang, Q., Bray, C.M. Plant J. (2002) [Pubmed]
Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70. Riha, K., Watson, J.M., Parkey, J., Shippen, D.E. EMBO J. (2002) [Pubmed]
Arabidopsis DNA double-strand break repair pathways. West, C.E., Waterworth, W.M., Sunderland, P.A., Bray, C.M. Biochem. Soc. Trans. (2004) [Pubmed]

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